Systematic LC/MS metabolite identification in drug discovery

被引:164
作者
Clarke, N [1 ]
Rindgen, D [1 ]
Korfmacher, W [1 ]
Cox, K [1 ]
机构
[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA
关键词
D O I
10.1021/ac012480y
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
引用
收藏
页码:430A / 439A
页数:10
相关论文
共 17 条
[1]   Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats [J].
Cox, KA ;
Dunn-Meynell, K ;
Korfmacher, WA ;
Broske, L ;
Nomeir, AA ;
Lin, CC ;
Cayen, MN ;
Barr, WH .
DRUG DISCOVERY TODAY, 1999, 4 (05) :232-237
[2]   Cytochrome P450 enzymes and drug metabolism - Basic concepts and methods of assessment [J].
Glue, P ;
Clement, RP .
CELLULAR AND MOLECULAR NEUROBIOLOGY, 1999, 19 (03) :309-323
[3]   HPLC-API/MS/MS: a powerful tool for integrating drug metabolism into the drug discovery process [J].
Korfmacher, WA ;
Cox, KA ;
Bryant, MS ;
Veals, J ;
Ng, K ;
Watkins, R ;
Lin, CC .
DRUG DISCOVERY TODAY, 1997, 2 (12) :532-537
[4]  
Kreutner W, 2000, ARZNEIMITTEL-FORSCH, V50, pE345
[5]  
LEE WM, 1993, ALIMENT PHARM THERAP, V7, P477
[6]   Rapid drug metabolite profiling using fast liquid chromatography, automated multiple-stage mass spectrometry and receptor-binding [J].
Lim, HK ;
Stellingweif, S ;
Sisenwine, S ;
Chan, KW .
JOURNAL OF CHROMATOGRAPHY A, 1999, 831 (02) :227-241
[7]  
Loo JA, 1999, MED RES REV, V19, P307, DOI 10.1002/(SICI)1098-1128(199907)19:4<307::AID-MED4>3.3.CO
[8]  
2-U
[9]   INSTRUMENTATION, APPLICATIONS, AND ENERGY DEPOSITION IN QUADRUPOLE ION-TRAP TANDEM MASS-SPECTROMETRY [J].
LOURIS, JN ;
COOKS, RG ;
SYKA, JEP ;
KELLEY, PE ;
STAFFORD, GC ;
TODD, JFJ .
ANALYTICAL CHEMISTRY, 1987, 59 (13) :1677-1685
[10]  
McLuckey, 1988, MASS SPECTROMETRY MA