Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance

被引：23
作者：
Chun, Kyung-Soo [1 ]
Joo, Sang Hoon [2 ]
机构：
[1] Keimyung Univ, Coll Pharm, Daegu 42601, South Korea
[2] Daegu Catholic Univ, Dept Pharm, Gyongsan 38430, South Korea
来源：
BIOMOLECULES & THERAPEUTICS | 2022年 / 30卷 / 06期
关键词：
Reactive oxygen species; Cancer; Resistance; 5-Fluorouracil; HUMAN COLORECTAL-CANCER; CELL-CYCLE ARREST; LIVER-CANCER; CLINICAL-SIGNIFICANCE; OXIDATIVE STRESS; AMINOPEPTIDASE-N; ANTITUMOR-ACTIVITY; INDUCED APOPTOSIS; CARCINOMA CELLS; NADPH OXIDASE;
D O I：
10.4062/biomolther.2022.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
5-Fluorouracil (5-FU) remains to be an important chemotherapeutic drug for treating several cancers when targeted therapy is unavailable. Chemoresistance limits the clinical utility of 5-FU, and new strategies are required to overcome the resistance. Reactive oxygen species (ROS) and antioxidants are balanced differently in both normal and cancer cells. Modulating ROS can be one method of overcoming 5-FU resistance. This review summarizes selected compounds and endogenous cellular targets modulating ROS generation to overcome 5-FU resistance.
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收藏
页码：479 / 489
页数：11
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