Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern

被引：78

作者：

Ai, Jingwen ^{[1
]}

Zhang, Haocheng ^{[1
]}

Zhang, Qiran ^{[1
]}

Zhang, Yi ^{[1
]}

Lin, Ke ^{[1
]}

Fu, Zhangfan ^{[1
]}

Song, Jieyu ^{[1
]}

Zhao, Yuanhan ^{[1
]}

Fan, Mingxiang ^{[1
]}

Wang, Hongyu ^{[1
]}

Qiu, Chao ^{[1
]}

Zhou, Yang ^{[1
]}

Zhang, Wenhong ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Huashan Hosp, Shanghai Med Coll,Shanghai Key Lab Infect Dis & B, Natl Med Ctr Infect Dis,Dept Infect Dis, Shanghai, Peoples R China

[2] Fudan Univ, Huashan Hosp, Nat Clin Res Ctr Aging & Med, Shanghai, Peoples R China

[3] Fudan Univ, Shanghai Med Coll, Key Lab Med Mol Virol MOE MOH, Shanghai, Peoples R China

来源：

CELL RESEARCH | 2022年 / 32卷 / 01期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1038/s41422-021-00590-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：103 / 106

页数：4

共 10 条

[1] SARS-CoV-2-specific T cell immunity to structural proteins in inactivated COVID-19 vaccine recipients [J].

Deng, Yao ;

Li, Yu ;

Yang, Ren ;

Tan, Wenjie .

CELLULAR & MOLECULAR IMMUNOLOGY, 2021, 18 (08) :2040-2041

[2] SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3 [J].

Falsey, Ann R. ;

Frenck, Robert W., Jr. ;

Walsh, Edward E. ;

Kitchin, Nicholas ;

Absalon, Judith ;

Gurtman, Alejandra ;

Lockhart, Stephen ;

Bailey, Ruth ;

Swanson, Kena A. ;

Xu, Xia ;

Koury, Kenneth ;

Kalina, Warren ;

Cooper, David ;

Zou, Jing ;

Xie, Xuping ;

Xia, Hongjie ;

Tuereci, Ozlem ;

Lagkadinou, Eleni ;

Tompkins, Kristin R. ;

Shi, Pei-Yong ;

Jansen, Kathrin U. ;

Sahin, Ugur ;

Dormitzer, Philip R. ;

Gruber, William C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (17) :1627-1629

[3]

Feng S., NAT MED, DOI [10.1038/s41591-021-01540-1(2021), DOI 10.1038/S41591-021-01540-1(2021)]

[4] Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002) [J].

Flaxman, Amy ;

Marchevsky, Natalie G. ;

Jenkin, Daniel ;

Aboagye, Jeremy ;

Aley, Parvinder K. ;

Angus, Brian ;

Belij-Rammerstorfer, Sandra ;

Bibi, Sagida ;

Bittaye, Mustapha ;

Cappuccini, Federica ;

Cicconi, Paola ;

Clutterbuck, Elizabeth A. ;

Davies, Sophie ;

Dejnirattisai, Wanwisa ;

Dold, Christina ;

Ewer, Katie J. ;

Folegatti, Pedro M. ;

Fowler, Jamie ;

Hill, Adrian V. S. ;

Kerridge, Simon ;

Minassian, Angela M. ;

Mongkolsapaya, Juthathip ;

Mujadidi, Yama F. ;

Plested, Emma ;

Ramasamy, Maheshi N. ;

Robinson, Hannah ;

Sanders, Helen ;

Sheehan, Emma ;

Smith, Holly ;

Snape, Matthew D. ;

Song, Rinn ;

Woods, Danielle ;

Screaton, Gavin ;

Gilbert, Sarah C. ;

Voysey, Merryn ;

Pollard, Andrew J. ;

Lambe, Teresa .

LANCET, 2021, 398 (10304) :981-990

[5]

Guo W., 2021, CLIN MED, V38, DOI [10.1016/j.eclinm.2021.101010, DOI 10.1016/J.ECLINM.2021.101010]

[6] Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study [J].

Hillus, David ;

Schwarz, Tatjana ;

Tober-Lau, Pinkus ;

Vanshylla, Kanika ;

Hastor, Hana ;

Thibeault, Charlotte ;

Jentzsch, Stefanie ;

Helbig, Elisa T. ;

Lippert, Lena J. ;

Tscheak, Patricia ;

Schmidt, Marie Luisa ;

Riege, Johanna ;

Solarek, Andre ;

von Kalle, Christof ;

Dang-Heine, Chantip ;

Gruell, Henning ;

Kopankiewicz, Piotr ;

Suttorp, Norbert ;

Drosten, Christian ;

Bias, Harald ;

Seybold, Joachim ;

Klein, Florian ;

Kurth, Florian ;

Corman, Victor Max ;

Sander, Leif Erik .

LANCET RESPIRATORY MEDICINE, 2021, 9 (11) :1255-1265

[7]

Li J., MEDRXIV, DOI [10.1101/2021.09.03.21263062(2021), DOI 10.1101/2021.09.03.21263062(2021)]

[8] Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2 [J].

Nie, Jianhui ;

Li, Qianqian ;

Wu, Jiajing ;

Zhao, Chenyan ;

Hao, Huan ;

Liu, Huan ;

Zhang, Li ;

Nie, Lingling ;

Qin, Haiyang ;

Wang, Meng ;

Lu, Qiong ;

Li, Xiaoyu ;

Sun, Qiyu ;

Liu, Junkai ;

Fan, Changfa ;

Huang, Weijin ;

Xu, Miao ;

Wang, Youchun .

EMERGING MICROBES & INFECTIONS, 2020, 9 (01) :680-686

[9]

Pan H., MEDRXIV, DOI [10.1101/2021.07.23.21261026(2021), DOI 10.1101/2021.07.23.21261026(2021)]

[10] Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD-based protein subunit vaccine (ZF2001) against COVID-19 in adults: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials [J].

Yang, Shilong ;

Li, Yan ;

Dai, Lianpan ;

Wang, Jianfeng ;

He, Peng ;

Li, Changgui ;

Fang, Xin ;

Wang, Chenfei ;

Zhao, Xiang ;

Huang, Enqi ;

Wu, Changwei ;

Zhong, Zaixin ;

Wang, Fengze ;

Duan, Xiaomin ;

Tian, Siyu ;

Wu, Lili ;

Liu, Yan ;

Luo, Yi ;

Chen, Zhihai ;

Li, Fangjun ;

Li, Junhua ;

Yu, Xian ;

Ren, Hong ;

Liu, Lihong ;

Meng, Shufang ;

Yan, Jinghua ;

Hu, Zhongyu ;

Gao, Lidong ;

Gao, George F. .

LANCET INFECTIOUS DISEASES, 2021, 21 (08) :1107-1119

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