Macathiohydantoins P-R, three new thiohydantoin derivatives from Maca (Lepidium meyenii)

被引：2

作者：

Geng, Hui-Chun ^{[1
]}

Wang, Xue-Song ^{[1
]}

Liao, Yong-Jian ^{[2
]}

Qiu, Shi-Yu ^{[2
]}

Fang, Hai-Xian ^{[1
]}

Chen, Xing-Lian ^{[1
]}

Wang, Yun-Mei ^{[1
]}

Zhou, Min ^{[2
]}

机构：

[1] Yunnan Acad Agr Sci, Inst Qual Stand & Testing Technol, Kunming 650223, Yunnan, Peoples R China

[2] Yunnan Minzu Univ, Sch Ethn Med, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss & Minist Educ, Kunming 650031, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2022年 / 51卷

基金：

中国国家自然科学基金;

关键词：

Lepidium meyenii; Thiohydantoins; Racemic mixtures; Maca; Cytotoxicity; STRUCTURAL ELUCIDATION; A-C;

D O I：

10.1016/j.phytol.2022.07.007

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new thiohydantoins with a 2-thioxoimidazolidin-4-one nucleus, named macathiohydantoins P-R (1-3), along with one known analog (4), were isolated from the roots of Lepidium meyenii. Their structures were elucidated by means of analysis of extensive spectroscopic data, including D-1 NMR, D-2 NMR and HRESIMS. The thiohydantoins (1-4) were isolated as racemic mixtures, which were further separated by chiral semi-preparative HPLC to afford the corresponding enantiomers. Their absolute configuration of C-5 was assigned by comparison of optical rotation values with those reported in the literature. All thiohydantoin derivatives were evaluated for their cytotoxicities against five human cancer cell lines.

引用

页码：67 / 70

页数：4

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