One-Pot Synthesis of Difluoromethyl Thioethers from Thiourea and Diethyl Bromodifluoromethylphosphonate

被引：29
作者：
Ding, Tianqi [1 ]
Jiang, Lvqi [1 ]
Yi, Wenbin [1 ]
机构：
[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 01期
基金：
中国国家自然科学基金;
关键词：
TRIFLUOROMETHYLTHIOLATION REACTIONS; S-DIFLUOROMETHYLATION; POLAR REACTIONS; ARYL HALIDES; DIFLUOROCARBENE; THIOETHERIFICATION; BROMIDES; REAGENT; ETHERS; THIOLS;
D O I：
10.1021/acs.orglett.7b03538
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A straightforward one-pot synthesis of difluoromethyl thioethers from thiourea and diethyl bromodifluoromethylphosphonate has been developed. Thiourea is a cheap and friendly sulfur reagent, while diethyl bromodifluoromethylphosphonate is a low-cost and stable difluorocarbene precursor. The strategy enabled the introduction of SCF2H moieties into indoles, pyrroles, and activated arenes and formed a number of difluoromethyl thioethers.
引用
收藏
页码：170 / 173
页数：4
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