One-Pot Synthesis of Difluoromethyl Thioethers from Thiourea and Diethyl Bromodifluoromethylphosphonate

被引：30

作者：

Ding, Tianqi ^{[1
]}

Jiang, Lvqi ^{[1
]}

Yi, Wenbin ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 01期

基金：

中国国家自然科学基金;

关键词：

TRIFLUOROMETHYLTHIOLATION REACTIONS; S-DIFLUOROMETHYLATION; POLAR REACTIONS; ARYL HALIDES; DIFLUOROCARBENE; THIOETHERIFICATION; BROMIDES; REAGENT; ETHERS; THIOLS;

D O I：

10.1021/acs.orglett.7b03538

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward one-pot synthesis of difluoromethyl thioethers from thiourea and diethyl bromodifluoromethylphosphonate has been developed. Thiourea is a cheap and friendly sulfur reagent, while diethyl bromodifluoromethylphosphonate is a low-cost and stable difluorocarbene precursor. The strategy enabled the introduction of SCF2H moieties into indoles, pyrroles, and activated arenes and formed a number of difluoromethyl thioethers.

引用

页码：170 / 173

页数：4

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