The Autism Phenome Project: Toward Identifying Clinically Meaningful Subgroups of Autism

被引:25
作者
Nordahl, Christine Wu [1 ,2 ]
Andrews, Derek Sayre [1 ,2 ]
Dwyer, Patrick [3 ,4 ]
Waizbard-Bartov, Einat [1 ,2 ]
Restrepo, Bibiana [1 ,5 ]
Lee, Joshua K. [1 ,2 ]
Heath, Brianna [1 ,2 ]
Saron, Clifford [1 ,3 ]
Rivera, Susan M. [1 ,3 ,4 ]
Solomon, Marjorie [1 ,2 ]
Ashwood, Paul [1 ,6 ]
Amaral, David G. [1 ,2 ]
机构
[1] Univ Calif Davis, MIND Inst, Davis, CA 95616 USA
[2] Univ Calif Davis, Sch Med, Dept Psychiat & Behav Sci, Davis, CA 95616 USA
[3] Univ Calif Davis, Ctr Mind & Brain, Davis, CA USA
[4] Univ Calif Davis, Dept Psychol, Davis, CA USA
[5] Univ Calif Davis, Sch Med, Dept Pediat, Davis, CA USA
[6] Univ Calif Davis, Sch Med, Dept Med Microbiol & Immunol, Davis, CA USA
关键词
autism; MRI; heterogeneity; immune; development; gastrointestinal; ERP; females; SPECTRUM DISORDER; BRAIN ENLARGEMENT; YOUNG BOYS; CEREBROSPINAL-FLUID; CHILDREN; INDIVIDUALS; PREVALENCE; PHENOTYPES; INTERVIEW; SEVERITY;
D O I
10.3389/fnins.2021.786220
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
One of the most universally accepted facts about autism is that it is heterogenous. Individuals diagnosed with autism spectrum disorder have a wide range of behavioral presentations and a variety of co-occurring medical and mental health conditions. The identification of more homogenous subgroups is likely to lead to a better understanding of etiologies as well as more targeted interventions and treatments. In 2006, we initiated the UC Davis MIND Institute Autism Phenome Project (APP) with the overarching goal of identifying clinically meaningful subtypes of autism. This ongoing longitudinal multidisciplinary study now includes over 400 children and involves comprehensive medical, behavioral, and neuroimaging assessments from early childhood through adolescence (2-19 years of age). We have employed several strategies to identify sub-populations within autistic individuals: subgrouping by neural, biological, behavioral or clinical characteristics as well as by developmental trajectories. In this Mini Review, we summarize findings to date from the APP cohort and describe progress made toward identifying meaningful subgroups of autism.
引用
收藏
页数:9
相关论文
共 67 条
[1]   In Pursuit of Neurophenotypes: The Consequences of Having Autism and a Big Brain [J].
Amaral, David G. ;
Li, Deana ;
Libero, Lauren ;
Solomon, Marjorie ;
Van de Water, Judy ;
Mastergeorge, Ann ;
Naigles, Letitia ;
Rogers, Sally ;
Nordahl, Christine Wu .
AUTISM RESEARCH, 2017, 10 (05) :711-722
[2]  
American Psychiatric Association, 2022, Diagnostic and statistical manual of mental disorders, V5th ed., text rev., DOI [10.1176/appi.books.9780890425596, DOI 10.1176/APPI.BOOKS.9780890425596]
[3]   A Longitudinal Study of White Matter Development in Relation to Changes in Autism Severity Across Early Childhood [J].
Andrews, Derek Sayre ;
Lee, Joshua K. ;
Harvey, Danielle Jenine ;
Waizbard-Bartov, Einat ;
Solomon, Marjorie ;
Rogers, Sally J. ;
Nordahl, Christine Wu ;
Amaral, David G. .
BIOLOGICAL PSYCHIATRY, 2021, 89 (05) :424-432
[4]   A diffusion-weighted imaging tract-based spatial statistics study of autism spectrum disorder in preschool-aged children [J].
Andrews, Derek Sayre ;
Lee, Joshua K. ;
Solomon, Marjorie ;
Rogers, Sally J. ;
Amaral, David G. ;
Nordahl, Christine Wu .
JOURNAL OF NEURODEVELOPMENTAL DISORDERS, 2019, 11 (01)
[5]   Language Growth in Young Children with Autism: Interactions Between Language Production and Social Communication [J].
Blume, Jessica ;
Wittke, Kacie ;
Naigles, Letitia ;
Mastergeorge, Ann M. .
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2021, 51 (02) :644-665
[6]   Myeloid dendritic cells frequencies are increased in children with autism spectrum disorder and associated with amygdala volume and repetitive behaviors [J].
Breece, Elizabeth ;
Paciotti, Brian ;
Nordahl, Christine Wu ;
Ozonoff, Sally ;
Van de Water, Judy A. ;
Rogers, Sally J. ;
Amaral, David ;
Ashwood, Paul .
BRAIN BEHAVIOR AND IMMUNITY, 2013, 31 :69-75
[7]   Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report [J].
Buie, Timothy ;
Campbell, Daniel B. ;
Fuchs, George J., III ;
Furuta, Glenn T. ;
Levy, Joseph ;
Van de Water, Judy ;
Whitaker, Agnes H. ;
Atkins, Dan ;
Bauman, Margaret L. ;
Beaudet, Arthur L. ;
Carr, Edward G. ;
Gershon, Michael D. ;
Hyman, Susan L. ;
Jirapinyo, Pipop ;
Jyonouchi, Harumi ;
Kooros, Koorosh ;
Kushak, Rafail ;
Levitt, Pat ;
Levy, Susan E. ;
Lewis, Jeffery D. ;
Murray, Katherine F. ;
Natowicz, Marvin R. ;
Sabra, Aderbal ;
Wershil, Barry K. ;
Weston, Sharon C. ;
Zeltzer, Lonnie ;
Winter, Harland .
PEDIATRICS, 2010, 125 :S1-S18
[8]   Early Generalized Overgrowth in Autism Spectrum Disorder: Prevalence Rates, Gender Effects, and Clinical Outcomes [J].
Campbell, Daniel J. ;
Chang, Joseph ;
Chawarska, Katarzyna .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2014, 53 (10) :1063-1073
[9]   Maternal Immune Activation and Autism Spectrum Disorder: From Rodents to Nonhuman and Human Primates [J].
Careaga, Milo ;
Murai, Takeshi ;
Bauman, Melissa D. .
BIOLOGICAL PSYCHIATRY, 2017, 81 (05) :391-401
[10]   Immune Endophenotypes in Children With Autism Spectrum Disorder [J].
Careaga, Milo ;
Rogers, Sally ;
Hansen, Robin L. ;
Amaral, David G. ;
Van de Water, Judy ;
Ashwood, Paul .
BIOLOGICAL PSYCHIATRY, 2017, 81 (05) :434-441