Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales

被引：28

作者：

Prachyawarakorn, Vilailak ^{[1
,2
]}

Mahidol, Chulabhorn ^{[1
,2
,4
]}

Sureram, Sanya ^{[1
]}

Sangpetsiripan, Suwannee ^{[1
]}

Wiyakrutta, Suthep ^{[3
]}

Ruchirawat, Somsak ^{[1
,2
,4
]}

Kittakoop, Prasat ^{[1
,2
]}

机构：

[1] Chulabhorn Res Inst, Bangkok 10210, Thailand

[2] Chulabhorn Grad Inst, Bangkok, Thailand

[3] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand

[4] Mahidol Univ, Chulabhorn Res Ctr, Inst Sci & Technol Res & Dev, Bangkok 10400, Thailand

来源：

PLANTA MEDICA | 2008年 / 74卷 / 01期

关键词：

marine derived fungi; Pleosporales; diketopiperazines; phthalides; cytotoxicity;

D O I：

10.1055/s-2007-993783

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five metabolites, (Z)-6-benzylidene-3-hydroxy-m ethyl-1,4-dimethyl-3-methyl sulfanyl pi perazine-2,5-dione (1), (3S,3'R)-3-(3'-hydroxybutyl)-7-methoxyphthalide (2), (S)-3-butyl-7-methoxyphthalide (3), (3R,6R)-bisdethiodi(methylthio)hyalodendrin (4), and bis-N-norgliovictin (5), were isolated from the culture broth of the marine derived fungus of the order Pleosporales strain CRIF2. Compounds 1 and 2 are new fungal metabolites, while 3 was isolated for the first time as a natural product. Compounds 1, 3, and 4 exhibited only weak cytotoxic activity, while 5 was inactive at 50 mu g/mL.

引用

页码：69 / 72

页数：4

共 17 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[2]

Anstiss M, 2002, SYNLETT, P290

[3] Drug discovery from natural sources [J].

Chin, Young-Won ;

Balunas, Marcy J. ;

Chai, Hee Byung ;

Kinghorn, A. Douglas .

AAPS JOURNAL, 2006, 8 (02) :E239-E253

[4] Natural product extracts of plant and marine origin having antileukemia potential. The NCI experience [J].

Cragg, GM ;

Newman, DJ ;

Yang, SS .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (03) :488-498

[5] NUCLEAR MAGNETIC-RESONANCE ENANTIOMER REAGENTS - CONFIGURATIONAL CORRELATIONS VIA NUCLEAR MAGNETIC-RESONANCE CHEMICAL-SHIFTS OF DIASTEREOMERIC MANDELATE, O-METHYLMANDELATE, AND ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETATE (MTPA) ESTERS [J].

DALE, JA ;

MOSHER, HS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (02) :512-519

[6]

Eriksson O.E., 2006, Myconet, V12, P1

[7] Unique diketopiperazine dimers from the insect pathogenic fungus Verticillium hemipterigenum BCC 1449 [J].

Isaka, M ;

Palasarn, S ;

Rachtawee, P ;

Vimuttipong, S ;

Kongsaeree, P .

ORGANIC LETTERS, 2005, 7 (11) :2257-2260

[8]

KIRBY GW, 1998, J CHEM SOC PERK T 1, P301

[9] Two new depsipeptides from the marine fungus Spicellum roseum [J].

Kralj, Ana ;

Kehraus, Stefan ;

Krick, Anja ;

van Echten-Deckert, Gerhild ;

Koenig, Gabriele M. .

PLANTA MEDICA, 2007, 73 (04) :366-371

[10] EPIPOLYTHIOPIPERAZINEDIONE ANTIBIOTICS FROM PENICILLIUM-TURBATUM [J].

MICHEL, KH ;

CHANEY, MO ;

JONES, ND ;

HOEHN, MM ;

NAGARAJAN, R .

JOURNAL OF ANTIBIOTICS, 1974, 27 (01) :57-64

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