Phenolic constituents and anticancer properties of Morus alba (white mulberry) leaves

被引：58

作者：

Chan, Eric Wei Chiang ^{[1
]}

Wong, Siu Kuin ^{[2
]}

Tangah, Joseph ^{[3
]}

Inoue, Tomomi ^{[4
]}

Chan, Hung Tuck ^{[5
]}

机构：

[1] UCSI Univ, Fac Appl Sci, Kuala Lumpur 56000, Malaysia

[2] Xiamen Univ Malaysia, Sch Fdn Studies, Sepang 43900, Selangor, Malaysia

[3] Sabah Forestry Dept, Forest Res Ctr, Sandakan 90009, Sabah, Malaysia

[4] Natl Inst Environm Studies NIES, Ctr Environm Biol & Ecosyst Studies, Tsukuba, Ibaraki 3050053, Japan

[5] Univ Ryukyus, Secretariat Int Soc Mangrove Ecosyst ISME, Fac Agr, Okinawa 9030129, Japan

来源：

JOURNAL OF INTEGRATIVE MEDICINE-JIM | 2020年 / 18卷 / 03期

关键词：

Flavonoids; Benzofurans; Cytotoxic; Moracins; Morachalcones; Chalcomoracin; BIOACTIVE BENZOFURAN DERIVATIVES; HUMAN BREAST-CANCER; NF-KAPPA-B; ANTIOXIDANT ACTIVITY; L; LEAVES; INHIBITORY CONSTITUENTS; FLAVONOL GLYCOSIDES; HUMAN COLON; CELL-DEATH; APOPTOSIS;

D O I：

10.1016/j.joim.2020.02.006

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Flavonoids are by far the most dominant class of phenolic compounds isolated from Morus alba leaves (MAL). Other classes of compounds are benzofurans, phenolic acids, alkaloids, coumarins, chalcones and stilbenes. Major flavonoids are kuwanons, moracinflavans, moragrols and morkotins. Other major compounds include moracins (benzofurans), caffeoylquinic acids (phenolic acids) and morachalcones (chalcones). Research on the anticancer properties of MAL entailed in vitro and in vivo cytotoxicity of extracts or isolated compounds. Flavonoids, benzofurans, chalcones and alkaloids are classes of compounds from MAL that have been found to be cytotoxic towards human cancer cell lines. Further studies on the phytochemistry and anticancer of MAL are suggested. Sources of information were PubMed, PubMed Central, ScienceDirect, Google, Google Scholar, J-Stage, PubChem and China National Knowledge Infrastructure. (C) 2020 Shanghai Changhai Hospital. Published by Elsevier B.V. All rights reserved.

引用

页码：189 / 195

页数：7

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