Synthesis and biological evaluation of lipophilic iron chelators as protective agents from oxidative stress

被引:13
|
作者
Yavin, E
Kikkiri, R
Gil, S
Arad-Yellin, R
Yavin, E
Shanzer, A [1 ]
机构
[1] Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel
[2] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel
关键词
D O I
10.1039/b507385p
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Lipophilic Fe-III chelators were synthesized and shown to protect oligodendrial cells from oxidative damage induced by Fe-III and hydrogen peroxide.
引用
收藏
页码:2685 / 2687
页数:3
相关论文
共 50 条
  • [41] Fast biological iron chelators: kinetics of iron removal from human diferric transferrin by multidentate hydroxypyridonates
    Turcot, I
    Stintzi, A
    Xu, JD
    Raymond, KN
    JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2000, 5 (05): : 634 - 641
  • [42] Reduction of ultraviolet light-induced oxidative stress by amino acid-based iron chelators
    Kitazawa, M
    Iwasaki, K
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1999, 1473 (2-3): : 400 - 408
  • [43] UVB induced oxidative stress in human keratinocytes and protective effect of antioxidant agents
    Guang-Hui Jin
    Yang Liu
    Shun-Zi Jin
    Xiao-Dong Liu
    Shu-Zheng Liu
    Radiation and Environmental Biophysics, 2007, 46 : 61 - 68
  • [44] UVB induced oxidative stress in human keratinocytes and protective effect of antioxidant agents
    Jin, Guang-Hui
    Liu, Yang
    Jin, Shun-Zi
    Liu, Xiao-Dong
    Liu, Shu-Zheng
    RADIATION AND ENVIRONMENTAL BIOPHYSICS, 2007, 46 (01) : 61 - 68
  • [45] Synthesis and in vitro biological evaluation of lipophilic cation conjugated photosensitizers for targeting mitochondria
    Rajaputra, Pallavi
    Nkepang, Gregory
    Watley, Ryan
    You, Youngjae
    BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (02) : 379 - 387
  • [46] Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells
    Lee, Dahae
    Kim, Ki Hyun
    Moon, Sung Won
    Lee, Heesu
    Kang, Ki Sung
    Lee, Jae Wook
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (09) : 1929 - 1932
  • [47] Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors
    Prandina, Anthony
    Radix, Sylvie
    Le Borgne, Marc
    Jordheim, Lars Petter
    Bousfiha, Zineb
    Frohlich, Christopher
    Leiros, Hanna-Kirsti S.
    Samuelsen, Orjan
    Frovold, Espen
    Rongved, Pal
    Astrand, Ove Alexander Hogmoen
    TETRAHEDRON, 2019, 75 (11) : 1525 - 1540
  • [48] Iron Overload Inhibits Osteoblast Biological Activity Through Oxidative Stress
    He, Yin-Feng
    Ma, Yong
    Gao, Chao
    Zhao, Guo-yang
    Zhang, Lin-Lin
    Li, Guang-Fei
    Pan, Yun-Zhi
    Li, Kai
    Xu, You-Jia
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2013, 152 (02) : 292 - 296
  • [49] Iron Overload Inhibits Osteoblast Biological Activity Through Oxidative Stress
    Yin-Feng He
    Yong Ma
    Chao Gao
    Guo-yang Zhao
    Lin-Lin Zhang
    Guang-Fei Li
    Yun-Zhi Pan
    Kai Li
    You-Jia Xu
    Biological Trace Element Research, 2013, 152 : 292 - 296
  • [50] Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats
    Liu, Chongbin
    Wang, Rui
    Zhang, Bo
    Hu, Chen
    Zhang, Hong
    BIOLOGICAL RESEARCH, 2013, 46 (02) : 189 - 200