Synthesis and biological evaluation of lipophilic iron chelators as protective agents from oxidative stress

被引:13
|
作者
Yavin, E
Kikkiri, R
Gil, S
Arad-Yellin, R
Yavin, E
Shanzer, A [1 ]
机构
[1] Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel
[2] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel
关键词
D O I
10.1039/b507385p
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Lipophilic Fe-III chelators were synthesized and shown to protect oligodendrial cells from oxidative damage induced by Fe-III and hydrogen peroxide.
引用
收藏
页码:2685 / 2687
页数:3
相关论文
共 50 条
  • [1] Synthesis and biological evaluation of naphthyldesferrithiocin iron chelators
    Bergeron, RJ
    Wiegand, J
    Wollenweber, M
    McManis, JS
    Algee, SE
    RatliffThompson, K
    JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (08) : 1575 - 1581
  • [2] Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury
    Jansova, Hana
    Machacek, Miloslav
    Wang, Qin
    Haskova, Pavlina
    Jirkovska, Anna
    Potuckova, Eliska
    Kielar, Filip
    Franz, Katherine J.
    Simunek, Tomas
    FREE RADICAL BIOLOGY AND MEDICINE, 2014, 74 : 210 - 221
  • [3] SYNTHESIS AND BIOLOGICAL EVALUATION OF HYDROXAMATE-BASED IRON CHELATORS
    BERGERON, RJ
    WIEGAND, J
    MCMANIS, JS
    PERUMAL, PT
    JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (11) : 3182 - 3187
  • [4] Synthesis of masked bidentate and hexadentate iron chelators designed to reduce oxidative stress
    Dickens, Marina G.
    Daniel, Catherine L.
    Pham, David M.
    Franz, Katherine J.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [5] Synthesis and antiproliferative evaluation of some iron chelators as polyamine transporter targeting agents
    Nazifi, Seyed Mohamad Reza
    Sadeghi-aliabadi, Hojjat
    Fassihi, Afshin
    Aliomrani, Mehdi
    Saghaie, Lotfollah
    CANADIAN JOURNAL OF CHEMISTRY, 2019, 97 (08) : 629 - 635
  • [6] The role of antioxidants and iron chelators in the treatment of oxidative stress in thalassemia
    Fibach, Eitan
    Rachmilewitz, Eliezer A.
    COOLEY'S ANEMIA: NINTH SYMPOSIUM, 2010, 1202 : 10 - 16
  • [7] Effects of Iron Chelators on Pulmonary Iron Overload and Oxidative Stress in β-Thalassemic Mice
    Yatmark, Paranee
    Morales, Noppawan Phumala
    Chaisri, Urai
    Wichaiyo, Surasak
    Hemstapat, Warinkarn
    Srichairatanakool, Somdet
    Svasti, Saovaros
    Fucharoen, Suthat
    PHARMACOLOGY, 2015, 96 (3-4) : 192 - 199
  • [8] Iron chelators increase the resistance of Ataxia telangeictasia cells to oxidative stress
    Shackelford, RE
    Manuszak, RP
    Johnson, CD
    Hellrung, DJ
    Link, CJ
    Wang, SM
    DNA REPAIR, 2004, 3 (10) : 1263 - 1272
  • [9] Synthesis and evaluation of iron chelators with masked hydrophilic moieties
    Meijler, MM
    Arad-Yellin, R
    Cabantchik, ZI
    Shanzer, A
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (43) : 12666 - 12667
  • [10] Polyaminoquinoline Iron Chelators for Vectorization of Antiproliferative Agents: Design, Synthesis, and Validation
    Corce, Vincent
    Morin, Emmanuelle
    Guiheneuf, Solene
    Renault, Eric
    Renaud, Stephanie
    Cannie, Isabelle
    Tripier, Raphael
    Lima, Luis M. P.
    Julienne, Karine
    Gouin, Sebastien G.
    Loreal, Olivier
    Deniaud, David
    Gaboriau, Francois
    BIOCONJUGATE CHEMISTRY, 2012, 23 (09) : 1952 - 1968