Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases

被引：59

作者：

Langerak, A. W. ^{[5
]}

Davi, F. ^{[6
,7
]}

Ghia, P. ^{[1
,2
,3
,4
]}

Hadzidimitriou, A. ^{[8
]}

Murray, F. ^{[9
]}

Potter, K. N. ^{[10
]}

Rosenquist, R. ^{[9
]}

Stamatopoulos, K. ^{[8
,11
,12
]}

Belessi, C. ^{[13
]}

机构：

[1] Univ Vita Salute San Raffaele, Div Mol Oncol, Lab Cell Neoplasia B, I-20132 Milan, Italy

[2] Univ Vita Salute San Raffaele, Div Mol Oncol, Unit Lymphoid Malignancies, I-20132 Milan, Italy

[3] Univ Vita Salute San Raffaele, Dept Oncol, I-20132 Milan, Italy

[4] Ist Sci San Raffaele, Milan, Italy

[5] Univ Med Ctr Rotterdam, Erasmus MC, Dept Immunol, Rotterdam, Netherlands

[6] Hop La Pitie Salpetriere, Hematol Lab, Paris, France

[7] Univ Paris 06, Hop La Pitie Salpetriere, Paris, France

[8] Ctr Res & Technol Hellas, Inst Agrobiotechnol, Thessaloniki, Greece

[9] Uppsala Univ, Rudbeck Lab, Dept Immunol Genet & Pathol, Uppsala, Sweden

[10] Univ Southampton, Canc Sci Div, Southampton, Hants, England

[11] G Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece

[12] G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece

[13] Nikea Gen Hosp, Dept Hematol, Piraeus, Greece

来源：

LEUKEMIA | 2011年 / 25卷 / 06期

基金：

英国医学研究理事会;

关键词：

CLL; immunoglobulin; prognosis; IGHV; somatic mutation analysis; CHRONIC LYMPHOCYTIC-LEUKEMIA; IGHV GENE; PATHOGENETIC IMPLICATIONS; STEREOTYPED RECEPTORS; ALLELIC EXCLUSION; MUTATIONAL STATUS; REARRANGEMENT; EXPRESSION; PATTERNS; SUBSET;

D O I：

10.1038/leu.2011.49

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

prognostication in chronic lymphocytic leukemia (CLL) and the definition of standardized procedures has allowed reliable and reproducible results. Occasionally, a straightforward interpretation of the sequences is not possible because of the so-called 'problematic sequences' that do not fit the 'classic' interpretation and pose scientific questions at the cross-road between hematology and immunology. Thanks to a dedicated effort within the European Research Initiative on CLL (ERIC), we have now the possibility to present such cases, offer a scientific explanation and propose recommendations in terms of prognostication. Leukemia (2011) 25, 979-984; doi:10.1038/leu.2011.49; published online 1 April 2011

引用

页码：979 / 984

页数：6

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