Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases

被引：59
|
作者：
Langerak, A. W. [5 ]
Davi, F. [6 ,7 ]
Ghia, P. [1 ,2 ,3 ,4 ]
Hadzidimitriou, A. [8 ]
Murray, F. [9 ]
Potter, K. N. [10 ]
Rosenquist, R. [9 ]
Stamatopoulos, K. [8 ,11 ,12 ]
Belessi, C. [13 ]
机构：
[1] Univ Vita Salute San Raffaele, Div Mol Oncol, Lab Cell Neoplasia B, I-20132 Milan, Italy
[2] Univ Vita Salute San Raffaele, Div Mol Oncol, Unit Lymphoid Malignancies, I-20132 Milan, Italy
[3] Univ Vita Salute San Raffaele, Dept Oncol, I-20132 Milan, Italy
[4] Ist Sci San Raffaele, Milan, Italy
[5] Univ Med Ctr Rotterdam, Erasmus MC, Dept Immunol, Rotterdam, Netherlands
[6] Hop La Pitie Salpetriere, Hematol Lab, Paris, France
[7] Univ Paris 06, Hop La Pitie Salpetriere, Paris, France
[8] Ctr Res & Technol Hellas, Inst Agrobiotechnol, Thessaloniki, Greece
[9] Uppsala Univ, Rudbeck Lab, Dept Immunol Genet & Pathol, Uppsala, Sweden
[10] Univ Southampton, Canc Sci Div, Southampton, Hants, England
[11] G Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece
[12] G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece
[13] Nikea Gen Hosp, Dept Hematol, Piraeus, Greece
来源：
LEUKEMIA | 2011年 / 25卷 / 06期
基金：
英国医学研究理事会;
关键词：
CLL; immunoglobulin; prognosis; IGHV; somatic mutation analysis; CHRONIC LYMPHOCYTIC-LEUKEMIA; IGHV GENE; PATHOGENETIC IMPLICATIONS; STEREOTYPED RECEPTORS; ALLELIC EXCLUSION; MUTATIONAL STATUS; REARRANGEMENT; EXPRESSION; PATTERNS; SUBSET;
D O I：
10.1038/leu.2011.49
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
prognostication in chronic lymphocytic leukemia (CLL) and the definition of standardized procedures has allowed reliable and reproducible results. Occasionally, a straightforward interpretation of the sequences is not possible because of the so-called 'problematic sequences' that do not fit the 'classic' interpretation and pose scientific questions at the cross-road between hematology and immunology. Thanks to a dedicated effort within the European Research Initiative on CLL (ERIC), we have now the possibility to present such cases, offer a scientific explanation and propose recommendations in terms of prognostication. Leukemia (2011) 25, 979-984; doi:10.1038/leu.2011.49; published online 1 April 2011
引用
收藏
页码：979 / 984
页数：6
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