HIV-1 decreases the levels of neurotrophins in human lymphocytes

被引：27

作者：

Avdoshina, Valeriya ^{[1
]}

Garzino-Demo, Alfredo ^{[2
]}

Bachis, Alessia ^{[1
]}

Monaco, Maria C. G. ^{[3
]}

Maki, Pauline M. ^{[4
,5
]}

Tractenberg, Rochelle E. ^{[6
]}

Liu, Chenglong ^{[7
]}

Young, Mary A. ^{[7
]}

Mocchetti, Italo ^{[1
]}

机构：

[1] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20057 USA

[2] Univ Maryland, Dept Microbiol & Immunol, Inst Human Virol, Baltimore, MD 21201 USA

[3] NINDS, Lab Mol Med & Neurosci, NIH, Bethesda, MD 20892 USA

[4] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA

[5] Univ Illinois, Dept Psychol, Chicago, IL 60680 USA

[6] Georgetown Univ, Med Ctr, Dept Neurol, Washington, DC 20057 USA

[7] Georgetown Univ, Med Ctr, Dept Med, Washington, DC 20057 USA

来源：

AIDS | 2011年 / 25卷 / 08期

关键词：

WOMENS INTERAGENCY HIV; CHEMOKINE RECEPTORS; ALZHEIMERS-DISEASE; BRAIN; BDNF; CELLS; EXPRESSION; THYMUS; ABUSE; SERUM;

D O I：

10.1097/QAD.0b013e32834671b3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neurotrophins control cell survival. Therefore, we examined whether HIV-1 reduces neurotrophin levels. Serum of HIV-positive individuals exhibited lower concentrations of brain-derived neurotrophic factor (BDNF), but not of other neurotrophins, than HIV-negative individuals. In addition, R5 and X4 strains of HIV-1 decreased BDNF expression in T cells. Our results support the hypothesis that reduced levels of BDNF may be a risk factor for T-cell apoptosis and for neurological complications associated with HIV-1 infection.

引用

页码：1126 / 1128

页数：3

共 22 条

[1] Brain-derived neurotrophic factor modulates expression of chemokine receptors in the brain
Ahmed, Farid
Tessarollo, Lino
Thiele, Carol
Mocchetti, Italo
[J]. BRAIN RESEARCH, 2008, 1227 : 1 - 11
[2] ALOE L, 2005, NEUROBIOLOGY NEUROTR, P237
[3] Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor
Angelucci, Francesco
Ricci, Valerio
Pomponi, Massimiliano
Conte, Gianluigi
Mathe, Aleksander A.
Tonali, Pietro Attilio
Bria, Pietro
[J]. JOURNAL OF PSYCHOPHARMACOLOGY, 2007, 21 (08) : 820 - 825
[4] Neurotrophins and their receptors in human lingual tonsil: An immunohistochemical analysis
Artico, Marco
Bronzetti, Elena
Felici, Laura M.
Alicino, Valentina
Ionta, Brunella
Bronzetti, Benedetto
Magliulo, Giuseppe
Grande, Claudia
Zamai, Loris
Pasquantonio, Guido
De Vincentiis, Marco
[J]. ONCOLOGY REPORTS, 2008, 20 (05) : 1201 - 1206
[5] The Women's Interagency HIV Study: an observational cohort brings clinical sciences to the bench
Bacon, MC
von Wyl, V
Alden, C
Sharp, G
Robison, E
Hessol, N
Gange, S
Barranday, Y
Holman, S
Weber, K
Young, MA
[J]. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2005, 12 (09) : 1013 - 1019
[6] The Women's Interagency HIV Study
Barkan, SE
Melnick, SL
Preston-Martin, S
Weber, K
Kalish, LA
Miotti, P
Young, M
Greenblatt, R
Sacks, H
Feldman, J
[J]. EPIDEMIOLOGY, 1998, 9 (02) : 117 - 125
[7] Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
Berger, EA
Murphy, PM
Farber, JM
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 657 - 700
[8] Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons
Chen, ZY
Patel, PD
Sant, G
Meng, CX
Teng, KK
Hempstead, BL
Lee, FS
[J]. JOURNAL OF NEUROSCIENCE, 2004, 24 (18) : 4401 - 4411
[9] Elkabes S, 1996, J NEUROSCI, V16, P2508
[10] Massive lymphocyte apoptosis in the thymus of functionally deficient TrkB mice
Garcia-Suarez, O
Blanco-Gelaz, MA
Lopez, ML
Germana, A
Cabo, R
Díaz-Esnal, B
Silos-Santiago, I
Ciriaco, E
Vega, JA
[J]. JOURNAL OF NEUROIMMUNOLOGY, 2002, 129 (1-2) : 25 - 34

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