Influence of thyroid function in CPK serum levels

被引：1

作者：

de Lima, Josivan Gomes ^{[1
,2
]}

Coelho Nobrega, Lucia Helena ^{[1
,2
]}

Coelho Nobrega, Maria Lucia ^{[2
]}

dos Santos Junior, Antonio Correia ^{[1
]}

Fernandes, Flavia da Costa ^{[1
]}

Torres Medeiros de Mesquita, Deciara Jacome ^{[1
]}

Camara de Souza, Alexandre Barbosa ^{[1
]}

机构：

[1] Univ Fed Rio Grande Norte UFRN, HUOL, Natal, RN, Brazil

[2] CEN, Natal, RN, Brazil

来源：

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2012年 / 56卷 / 03期

关键词：

TSH; serum creatine kinase; free T4; hyperthyroidism; hypothyroidism; CREATINE-KINASE; HYPOTHYROIDISM; MYOGLOBIN; HORMONE; MUSCLE; HEART; RAT; HYPERTHYROIDISM; MITOCHONDRIAL; CHILDREN;

D O I：

10.1590/S0004-27302012000300007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To determine serum CPK variation based on TSH e free T4 (FT4), and to assess serum CPK in pathological states of the thyroid (hyperthyroidism and hypothyroidism), in relation to the euthyroidism. Materials and methods: We evaluated retrospectively 6,230 laboratory results of TSH and CPK from 2007 to 2011. From these, 3,369 had free T4 results. We evaluated the correlation between CPK and TSH and the pathological states of the thyroid. Results: The correlation between TSH and CPK was positive (r = 0.065), while that between CPK and FT4 was negative (r = -0.091, p < 0.05). From the total of results analyzed, 586 (9.4%) were measures of hyperthyroidism, with a median (range) of CPK of 98 U/L (27 to 1,113), and 556 (8.9%) were of hypothyroidism, with CPK of 114 U/L (25-4,182). Conclusion: A positive correlation was found between serum CPK and TSH, and a negative correlation between CPK and FT4. CPK was lower in the group with hyperthyroidism, and greater in that with hypothyroidism. Arq Bras Endocrinol Metab. 2012;56(3):190-4

引用

页码：190 / 194

页数：5

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