A practical synthesis of highly hindered biphenyl-2-carboxylates via nucleophilic aromatic substitution of tert-butyl 2-methoxybenzoates with aryl Grignard reagent

被引：10

作者：

Aki, S ^{[1
]}

Haraguchi, Y ^{[1
]}

Sakikawa, H ^{[1
]}

Ishigami, M ^{[1
]}

Fujioka, T ^{[1
]}

Furuta, T ^{[1
]}

Minamikawa, J ^{[1
]}

机构：

[1] Otsuka Pharmaceut Co Ltd, Tokushima Factory 2, Synth Lab, Tokushima 7710182, Japan

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2001年 / 5卷 / 05期

关键词：

D O I：

10.1021/op0001279

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The fluorenone derivative (OPC-34165) has potent repairing and protecting activities for peripheral and central nervous system degeneration. A synthesis of the biphenyl-2-carboxylic acid derivative, which is the key intermediate of OPC-34165, is described employing the SNAr reaction of tert-butyl 2-methoxybenzoate with aryl Grignard reagent in refluxing THF-toluene.

引用

页码：535 / 538

页数：4

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