Cadmium toxicity induces ER stress and apoptosis via impairing energy homoeostasis in cardiomyocytes

被引:63
作者
Chen, Chun-yan [1 ]
Zhang, Shao-li [2 ]
Liu, Zhi-yong [3 ]
Tian, Yong [1 ]
Sun, Qian [1 ]
机构
[1] Peoples Hosp Zhengzhou, Dept Geriatr, Zhengzhou 450012, Peoples R China
[2] Xinxiang Med Univ, Affiliated Hosp 1, Dept Cardiol, Jiankang 453100, Xinxiang, Peoples R China
[3] Peoples Hosp Dezhou, Dept Internal Med, Dezhou 253014, Peoples R China
关键词
AKT/mammalian target of rapamycin (mTOR); cardiomyocytes; cadmium toxicity; energy metabolism; endoplasmic reticulum (ER) stress; RAT-HEART; TRIGGERS APOPTOSIS; HEAVY-METAL; CARDIOTOXICITY; METABOLISM; DISEASE; FAILURE; CALCIUM; PATHWAY; DEATH;
D O I
10.1042/BSR20140170
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cadmium, a highly toxic environmental pollutant, is reported to induce toxicity and apoptosis in multiple organs and cells, all possibly contributing to apoptosis in certain pathophysiologic situations. Previous studies have described that cadmium toxicity induces biochemical and physiological changes in the heart and finally leads to cardiac dysfunctions, such as decreasing contractile tension, rate of tension development, heart rate, coronary flow rate and atrioventricular node conductivity. Although many progresses have been made, the mechanism responsible for cadmium-induced cellular alternations and cardiac toxicity is still not fully understood. In the present study, we demonstrated that cadmium toxicity induced dramatic endoplasmic reticulum (ER) stress and impaired energy homoeostasis in cultured cardiomyocytes. Moreover, cadmium toxicity may inhibit protein kinase B (AKT)/mTOR (mammalian target of rapamycin) pathway to reduce energy productions, by either disrupting the glucose metabolism or inhibiting mitochondrial respiratory gene expressions. Our work will help to reveal a novel mechanism to clarify the role of cadmium toxicity to cardiomyocytes and provide new possibilities for the treatment of cardiovascular diseases related to cadmium toxicity.
引用
收藏
页码:1 / 8
页数:8
相关论文
共 30 条
[1]   Energy Metabolism in Cardiac Remodeling and Heart Failure [J].
Azevedo, Paula S. ;
Minicucci, Marcos F. ;
Santos, Priscila P. ;
Paiva, Sergio A. R. ;
Zornoff, Leonardo A. M. .
CARDIOLOGY IN REVIEW, 2013, 21 (03) :135-140
[2]   Metabolic homeostasis of the heart [J].
Balaban, Robert S. .
JOURNAL OF GENERAL PHYSIOLOGY, 2012, 139 (06) :407-414
[3]   Cardiac energy metabolism homeostasis: Role of cytosolic calcium [J].
Balaban, RS .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2002, 34 (10) :1259-1271
[4]   RELATIONSHIP OF CADMIUM IN AIR TO CARDIOVASCULAR DISEASE DEATH RATES [J].
CARROLL, RE .
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1966, 198 (03) :267-&
[5]   Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1 [J].
Duevel, Katrin ;
Yecies, Jessica L. ;
Menon, Suchithra ;
Raman, Pichai ;
Lipovsky, Alex I. ;
Souza, Amanda L. ;
Triantafellow, Ellen ;
Ma, Qicheng ;
Gorski, Regina ;
Cleaver, Stephen ;
Heiden, Matthew G. Vander ;
MacKeigan, Jeffrey P. ;
Finan, Peter M. ;
Clish, Clary B. ;
Murphy, Leon O. ;
Manning, Brendan D. .
MOLECULAR CELL, 2010, 39 (02) :171-183
[6]   Protective role of selenium against renal toxicity induced by cadmium in rats [J].
El-Sharaky, A. S. ;
Newairy, A. A. ;
Badreldeen, M. M. ;
Eweda, S. M. ;
Sheweita, S. A. .
TOXICOLOGY, 2007, 235 (03) :185-193
[7]   Cadmium Induces Liver Cell Apoptosis through Caspase-3A Activation in Purse Red Common Carp (Cyprinus carpio) [J].
Gao, Dian ;
Xu, Zhen'e ;
Qiao, Panpan ;
Liu, Shen ;
Zhang, Li ;
He, Penghui ;
Zhang, Xiaoyan ;
Wang, Yannan ;
Min, Weiping .
PLOS ONE, 2013, 8 (12)
[8]   Relating cardiac performance with oxygen consumption: historical observations continue to spawn scientific discovery [J].
Gutterman, David D. ;
Cowley, Allen W., Jr. .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2006, 291 (06) :H2555-H2556
[9]   The Akt/mTOR Pathway Assures the Synthesis of HIF-1α Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors [J].
Harada, Hiroshi ;
Itasaka, Satoshi ;
Kizaka-Kondoh, Shinae ;
Shibuya, Keiko ;
Morinibu, Akiyo ;
Shinomiya, Kazumi ;
Hiraoka, Masahiro .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (08) :5332-5342
[10]   Rapid, transient induction of ER stress in the liver and kidney after acute exposure to heavy metal: Evidence from transgenic sensor mice [J].
Hiramatsu, Nobuhiko ;
Kasai, Ayumi ;
Du, Shuqi ;
Takeda, Masayuki ;
Hayakawa, Kunihiro ;
Okamura, Maro ;
Yao, Jian ;
Kitamura, Masanori .
FEBS LETTERS, 2007, 581 (10) :2055-2059