Multifunctional 3D Patternable Drug-Embedded Nanocarrier-Based Interfaces to Enhance Signal Recording and Reduce Neuron Degeneration in Neural Implantation

被引：21

作者：

Huang, Wei-Chen ^{[1
]}

Lai, Hsin-Yi ^{[2
]}

Kuo, Li-Wei ^{[3
]}

Liao, Chia-Hsin ^{[4
]}

Chang, Po-Hsieh ^{[1
]}

Liu, Ta-Chung ^{[1
]}

Chen, San-Yuan ^{[1
]}

Chen, You-Yin ^{[5
]}

机构：

[1] Natl Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu 30010, Taiwan

[2] Zhejiang Univ, Qiushi Acad Adv Studies, Interdisciplinary Inst Neurosci & Technol, Hangzhou 310029, Zhejiang, Peoples R China

[3] Natl Hlth Res Inst, Inst Biomed Engn & Nanomed, Miaoli 35053, Taiwan

[4] Buddhist Tzu Chi Gen Hosp, Dept Med Res, Hualien 97002, Taiwan

[5] Natl Yang Ming Univ, Dept Biomed Engn, Taipei 11221, Taiwan

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 28期

关键词：

neural implant; neural interface; drug delivery; nanocarrier(s); hydrogel; CONDUCTING-POLYMER NANOTUBES; CROSS-LINKING; HYDROGELS; PROANTHOCYANIDIN; FABRICATION; MICROELECTRODES; STIMULATION; STABILITY; COATINGS; RELEASE;

D O I：

10.1002/adma.201500136

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To improve the long-term performance of a neural implant, a nanocarrier-based neural interface is developed by implementing nanomanufacturing technology and multifunctional nanomaterials to provide structural and mechanical properties that mimic brain tissue, sustain the nonfouling property, and prolong the anti-inflammatory ability. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4186 / 4193

页数：8