共 18 条
Mini-electrochemical detector for microchip electrophoresis
被引:24
作者:

Jiang, L
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机构: Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Lu, Y
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机构: Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Dai, ZP
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h-index: 0
机构: Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Xie, MH
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机构: Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Lin, BC
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机构:
Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
机构:
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Dalian 116023, Peoples R China
[3] Beijing Sport Univ, Dept Human Sport Sci, Beijing 100084, Peoples R China
关键词:
D O I:
10.1039/b505467b
中图分类号:
Q5 [生物化学];
学科分类号:
071010 ;
081704 ;
摘要:
This paper presents the development of a mini-electrochemical detector for microchip electrophoresis. The small size (3.6 x 5.0 cm(2), W x L) of the detector is compatible with the dimension of the microchip. The use of universal serial bus (USB) ports facilitates installation and use of the detector, miniaturizes the detector, and makes it ideal for lab-on-a-chip applications. A fixed 10 M Omega feedback resistance was chosen to convert current of the working electrode to voltage with second gain of 1, 2, 4, 8, 16, 32, 64 and 128 for small signal detection instead of adopting selectable feedback resistance. Special attention has been paid to the power support circuitry and printed circuit board (PCB) design in order to obtain good performance in such a miniature size. The working electrode potential could be varied over a range of +/-2.5 V with a resolution of 0.01 mV. The detection current ranges from -0.3 x 10(-7) A to 2.5 x 10(-7) A and the noise is lower than 1 pA. The analytical performance of the new system was demonstrated by the detection of epinephrine using an integrated PDMS/glass microchip with detection limit of 2.1 mu M (S/N = 3).
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页码:930 / 934
页数:5
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