Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology

被引：112

作者：

Fu, Ya ^{[1
]}

Rubin, Charles S. ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

来源：

EMBO REPORTS | 2011年 / 12卷 / 08期

基金：

美国国家卫生研究院;

关键词：

protein kinase D; diacylglycerol; PKD effectors; PKD functions; PKD regulation; PKD inhibitors; MATRIX-METALLOPROTEINASE EXPRESSION; D-MEDIATED PHOSPHORYLATION; PLASMA-MEMBRANE TRANSPORT; ACTIVATION LOOP SER(744); HISTONE DEACETYLASE 7; NF-KAPPA-B; IN-VIVO; PROSTATE-CANCER; C-MU; G(Q)-COUPLED RECEPTORS;

D O I：

10.1038/embor.2011.139

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein kinase D (PKD) mediates the actions of stimuli that promote diacylglycerol (DAG) biogenesis. By phosphorylating effectors that regulate transcription, fission and polarized transport of Golgi vesicles, as well as cell migration and survival after oxidative stress, PKDs substantially expand the range of physiological processes controlled by DAG. Dysregulated PKDs have been linked to pathologies including heart hypertrophy and cancer invasiveness. Our understanding of PKD regulation by trans-and auto-phosphorylation, as well as the sub-cellular dynamics of PKD substrate phosphorylation, have increased markedly. Selective PKD inhibitors provide new, powerful tools for elucidating the physiological roles of PKDs and potentially treating cardiac disease and cancer.

引用

页码：785 / 796

页数：12

共 81 条

[1] The selectivity of protein kinase inhibitors: a further update [J].

Bain, Jenny ;

Plater, Lorna ;

Elliott, Matt ;

Shpiro, Natalia ;

Hastie, C. James ;

Mclauchlan, Hilary ;

Klevernic, Iva ;

Arthur, J. Simon C. ;

Alessi, Dario R. ;

Cohen, Philip .

BIOCHEMICAL JOURNAL, 2007, 408 :297-315

[2] The formation of TGN-to-plasma-membrane transport carriers [J].

Bard, Frederic ;

Malhotra, Vivek .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2006, 22 :439-455

[3] Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane [J].

Baron, CL ;

Malhotra, V .

SCIENCE, 2002, 295 (5553) :325-328

[4] Protein kinase D regulates trafficking of dendritic membrane proteins in developing neurons [J].

Bisbal, Mariano ;

Conde, Cecilia ;

Donoso, Maribel ;

Bollati, Flavia ;

Sesma, Juliana ;

Quiroga, Santiago ;

Diaz Anel, Alberto ;

Malhotra, Vivek ;

Paz Marzolo, Maria ;

Caceres, Alfredo .

JOURNAL OF NEUROSCIENCE, 2008, 28 (37) :9297-9308

[5] Dimeric PKD regulates membrane fission to form transport carriers at the TGN [J].

Bossard, Carine ;

Bresson, Damien ;

Polishchuk, Roman S. ;

Malhotra, Vivek .

JOURNAL OF CELL BIOLOGY, 2007, 179 (06) :1123-1131

[6] Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCε/PKD3 pathway downstream of Akt and ERK 1/2 [J].

Chen, Jun ;

Deng, Fan ;

Singh, Shivendra V. ;

Wang, Qiming J. .

CANCER RESEARCH, 2008, 68 (10) :3844-3853

[7] Loss of Cell-Cell Contacts Induces NF-κB Via RhoA-Mediated Activation of Protein Kinase D1 [J].

Cowell, Catherine F. ;

Yan, Irene K. ;

Eiseler, Tim ;

Leightner, Amanda C. ;

Doeppler, Heike ;

Storz, Peter .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2009, 106 (04) :714-728

[8] Mitochondrial diacylglycerol initiates protein-kinase-D1-mediated ROS signaling [J].

Cowell, Catherine F. ;

Doeppler, Heike ;

Yan, Irene K. ;

Hausser, Angelika ;

Umezawa, Yoshio ;

Storz, Peter .

JOURNAL OF CELL SCIENCE, 2009, 122 (07) :919-928

[9] Protein kinase D selectively targets cardiac troponin I and regulates myofilament Ca2+ sensitivity in ventricular myocytes [J].

Cuello, Friederike ;

Bardswell, Sonya C. ;

Haworth, Robert S. ;

Yin, Xiaoke ;

Lutz, Susanne ;

Wieland, Thomas ;

Mayr, Manuel ;

Kentish, Jonathan C. ;

Avkiran, Metin .

CIRCULATION RESEARCH, 2007, 100 (06) :864-873

[10] Protein Kinase D Controls the Integrity of Golgi Apparatus and the Maintenance of Dendritic Arborization in Hippocampal Neurons [J].

Czoendoer, Katalin ;

Ellwanger, Kornelia ;

Fuchs, Yannick F. ;

Lutz, Sylke ;

Gulyas, Marton ;

Mansuy, Isabelle M. ;

Hausser, Angelika ;

Pfizenmaier, Klaus ;

Schlett, Katalin .

MOLECULAR BIOLOGY OF THE CELL, 2009, 20 (07) :2108-2120

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