Lipid Bilayer Reorganization under Extreme pH Conditions

被引：18

作者：

Goertz, Matthew P. ^{[1
]}

Goyal, Nikita ^{[2
]}

Montano, Gabriel A. ^{[2
]}

Bunker, Bruce C. ^{[1
]}

机构：

[1] Sandia Natl Labs, Ctr Integrated Nanotechnol, Albuquerque, NM 87185 USA

[2] Los Alamos Natl Labs, Los Alamos, NM 87545 USA

来源：

LANGMUIR | 2011年 / 27卷 / 09期

关键词：

FLUORESCENCE MICROSCOPY; MEMBRANES; PHOSPHOLIPIDS; HYDROLYSIS; LIPOSOMES; DIFFUSION;

D O I：

10.1021/la2001305

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Supported lipid bilayers containing phosphatidylcholine headgroups are observed to undergo reorganization from a 2D fluid, lipid bilayer assembly into an array of complex 3D structures upon exposure to extreme pH environments. These conditions induce a combination of molecular packing and electrostatic interactions that can create dynamic morphologies of highly curved lipid membrane structures. This work demonstrates that fluid, single-component lipid bilayer assemblies can create complex morphologies, a phenomenon typically only associated with lipid bilayers of mixed composition.

引用

页码：5481 / 5491

页数：11

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