CCL5 induces a pro-inflammatory profile in microglia in vitro

被引：87

作者：

Skuljec, Jelena ^{[1
,2
]}

Sun, Hui ^{[1
,2
]}

Pul, Refik ^{[1
]}

Benardais, Karelle ^{[1
,2
]}

Ragancokova, Daniela ^{[1
,2
]}

Moharregh-Khiabani, Darius ^{[1
]}

Kotsiari, Alexandra ^{[1
]}

Trebst, Corinna ^{[1
]}

Stangel, Martin ^{[1
,2
]}

机构：

[1] Hannover Med Sch, Dept Neurol, D-30625 Hannover, Germany

[2] Ctr Syst Neurosci, Hannover, Germany

来源：

CELLULAR IMMUNOLOGY | 2011年 / 270卷 / 02期

关键词：

Microglia; Chemokines; CCL2; CCL3; CCL5; CXCL1; Immunomodulation; CENTRAL-NERVOUS-SYSTEM; MONOCYTE CHEMOATTRACTANT PROTEIN-1; MULTIPLE-SCLEROSIS LESIONS; CHEMOKINE RECEPTORS; BETA-CHEMOKINES; ALZHEIMERS-DISEASE; NITRIC-OXIDE; EXPRESSION; BRAIN; CCR5;

D O I：

10.1016/j.cellimm.2011.05.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The chemokine receptors CCR1, CCR2, CCR3, CCR5, and CXCR2 have been found to be expressed on microglia in many neurodegenerative diseases, such as multiple sclerosis and Alzheimer's disease. There is emerging evidence that chemokines, besides chemoattraction, might directly modulate reactive profiles of microglia. To address this hypothesis we have investigated the effects of CCL2, CCL3, CCL5, and CXCL1 on cytokine and growth factor production, NO synthesis, and phagocytosis in non-stimulated and lipopolysaccharide-stimulated primary rat microglia. The respective receptors CCR1, CCR5, and CXCR2 were shown to be functionally expressed on microglia. All tested chemokines stimulated chemotaxis whereas only CCL5 increased NO secretion and attenuated IL-10 as well as IGF-1 production in activated microglia. Based on these findings we propose that besides its chemoattractant function CCL5 has a modulatory effect on activated microglia. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：164 / 171

页数：8

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