Preparation and in vivo evaluation of mucoadhesive microparticles containing amoxycillin-resin complexes for drug delivery to the gastric mucosa

被引：48

作者：

Cuña, M ^{[1
]}

Alonso, MJ ^{[1
]}

Torres, D ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Fac Pharm, Dept Pharm & Pharmaceut Technol, E-15706 Santiago De Compostela, Spain

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2001年 / 51卷 / 03期

关键词：

polycarbophil; Carbopol; 934; mucoadhesive microparticle; ion exchange resin; gastrointestinal transit; Helicobacter pylori; amoxycillin;

D O I：

10.1016/S0939-6411(01)00124-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this work, microparticles consisting of amoxycillin-loaded ion-exchange resin encapsulated in mucoadhesive polymers (polycarbophil and Carbopol 934) were prepared with the aim of increasing the efficacy of amoxycillin in the treatment of peptic ulcers by achieving targeted delivery to the gastric mucosa and prolonged drug release. An oil-in-oil solvent evaporation technique was conveniently modified in order to obtain polymer microparticles containing multiple amoxycillin-resin cores. Polycarbophil microparticles were spherical, Carbopol 934 microparticles irregular. In vitro release of amoxycillin was rapid with or without a polymer coating. Gastrointestinal transit in rats was investigated by fluorescence microscopy using particles loaded with fluorescein instead of amoxycillin: gastric residence time was longer, and the distribution of the particles on the mucosa apparently better, without any polymer coating. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：199 / 205

页数：7

共 36 条

[1] Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites [J].