Effects of dynamic changes of tissue properties during laser-induced interstitial thermotherapy (LITT)

被引：44

作者：

Jiang, SC ^{[1
]}

Zhang, XX ^{[1
]}

机构：

[1] Tsing Hua Univ, Dept Thermal Engn, Key Lab Thermal Sci & Power Engn, Beijing 100084, Peoples R China

来源：

LASERS IN MEDICAL SCIENCE | 2005年 / 19卷 / 04期

基金：

中国国家自然科学基金;

关键词：

laser-induced interstitial thermotherapy; Monte Carlo; bioheat transfer; dynamic properties; thermal damage;

D O I：

10.1007/s10103-004-0324-8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A two-dimensional model including the effects of dynamic changes in the physical properties on tissue temperature and damage was developed to describe laser energy transport, heat transfer, and damage accumulation during laser-induced interstitial thermotherapy (LITT). The Monte Carlo method was used to simulate photon transport in a tissue in the nonuniform optical property field, with the finite difference method used to solve the Pennes bioheat equation to calculate the temperature distribution and the Arrhenius equation used to predict the extent of thermal damage. The numerical results showed that the dynamic changes in the optical properties, thermal properties, and blood perfusion rate significantly affected damage volume accumulation and temperature history and should be included in numerical simulations of the LITT treatment.

引用

页码：197 / 202

页数：6

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