Four new iridoid glucosides containing the furan ring from the fruit of Corpus officinalis

被引：24

作者：

He, Jun ^{[1
]}

Ye, Xian-Sheng ^{[2
,3
]}

Wang, Xiao-Xue ^{[1
]}

Yang, Ya-Nan ^{[4
,5
]}

Zhang, Pei-Cheng ^{[4
,5
]}

Ma, Bing-Zhi ^{[1
]}

Zhang, Wei-Ku ^{[2
]}

Xu, Jie-Kun ^{[6
]}

机构：

[1] China Japan Friendship Hosp, Dept Pharm, Beijing 100029, Peoples R China

[2] China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China

[3] Beijing Univ Chinese Med, Sch Chinese Med Sci, Beijing 100029, Peoples R China

[4] Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[5] Chinese Acad Med Sci, Beijing 100050, Peoples R China

[6] Beijing Univ Chinese Med, Sch Life Sci, Beijing 100029, Peoples R China

来源：

FITOTERAPIA | 2017年 / 120卷

基金：

中国国家自然科学基金;

关键词：

Comas officinalis; Cornusfuroside A-D; Furan ring; Neuroprotective effect; FOCAL CEREBRAL-ISCHEMIA; CORNUS-OFFICINALIS; MORRONISIDE; FRUCTUS; CELLS;

D O I：

10.1016/j.fitote.2017.06.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new and rare iridoid glucosides, cornusfuroside A-D (1-4), containing the furan ring were identified from water extract of the fruit of Cornus officinalis. These new chemical structures were determined through extensive spectroscopic analysis, including 1D and 2D NMR, IR, HRESIMS, experimental and calculated electronic circular dichroism (ECD). Notably, this study is the first report on the isolation of four iridoid glucoside structures with acetal functions in the sugar moiety. The neuroprotective effects of these compounds were also evaluated in vitro.

引用

页码：136 / 141

页数：6

共 19 条

[1] Cornus officinalis methanol extract upregulates melanogenesis in melan-a cells [J].

An Y.A. ;

Hwang J.Y. ;

Lee J.S. ;

Kim Y.C. .

Toxicological Research, 2015, 31 (2) :165-172

[2] Chemoprevention against hepatocellular carcinoma of Cornus officinalis in vitro [J].

Chang, JS ;

Chiang, LC ;

Hsu, FF ;

Lin, CC .

AMERICAN JOURNAL OF CHINESE MEDICINE, 2004, 32 (05) :717-725

[3] Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death [J].

Chen, Chien-Chih ;

Hsu, Chia-Yun ;

Chen, Chin-Ying ;

Liu, Hui-Kang .

JOURNAL OF ETHNOPHARMACOLOGY, 2008, 117 (03) :483-490

[4]

China Flora Editorial Board (Chinese Academy of Sciences), 1990, FLOR CHIN, V56, P83

[5]

Chinese Pharmacopoeia Commission, 2015, PHARMACOPOEIA PEOPLE, V1, P27

[6]

Han S. Y., 2004, CHINESE ARCH TRADITI, V22, P56

[7] Neuroprotective iridoid glycosides from Cornus officinalis fruits against glutamate-induced toxicity in HT22 hippocampal cells [J].

Jeong, Eun Ju ;

Kim, Tae Bum ;

Yang, Heejung ;

Kang, So Young ;

Kim, Sun Yeou ;

Sung, Sang Hyun ;

Kim, Young Choong .

PHYTOMEDICINE, 2012, 19 (3-4) :317-321

[8] Protective roles of cornuside in acute myocardial ischemia and reperfusion injury in rats [J].

Jiang, Wang-Lin ;

Zhang, Shu-Min ;

Tang, Xue-Xi ;

Liu, Hong-Zhan .

PHYTOMEDICINE, 2011, 18 (04) :266-271

[9] Cornuside suppresses cytokine-induced proinflammatory and adhesion molecules in the human umbilical vein endothelial cells [J].

Kang, Dae Gill ;

Moon, Mi Kyoung ;

Lee, An Sook ;

Kwon, Tae Oh ;

Kim, Jin Sook ;

Lee, Ho Sub .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2007, 30 (09) :1796-1799

[10] Galloyl Glucoses from the Seeds of Cornus officinalis with Inhibitory Activity against Protein Glycation, Aldose Reductase, and Cataractogenesis ex Vivo [J].

Lee, Jun ;

Jang, Dae Sik ;

Kim, Nan Hee ;

Lee, Yun Mi ;

Kim, Junghyun ;

Kim, Jin Sook .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2011, 34 (03) :443-446

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