Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment

被引：92

作者：

Chong, Yu ^{[1
]}

Dai, Xing ^{[1
]}

Fang, Ge ^{[1
]}

Wu, Renfei ^{[1
]}

Zhao, Lin ^{[1
]}

Ma, Xiaochuan ^{[1
]}

Tian, Xin ^{[1
]}

Lee, Sangyun ^{[2
]}

Zhang, Chao ^{[3
]}

Chen, Chunying ^{[4
,5
,6
]}

Chai, Zhifang ^{[1
]}

Ge, Cuicui ^{[1
]}

Zhou, Ruhong ^{[1
,2
,7
]}

机构：

[1] Soochow Univ, State Key Lab Radiat Med & Protect, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Peoples R China

[2] IBM Thomas J Watson Res Ctr, Computat Biol Ctr, Yorktown Hts, NY 10598 USA

[3] Anhui Univ Sci & Technol, Sch Mat Sci & Engn, Huainan 232001, Peoples R China

[4] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[5] Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China

[6] Univ Chinese Acad Sci, Beijing 100190, Peoples R China

[7] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

中国国家自然科学基金;

关键词：

VITAMIN-C PHARMACOKINETICS; I CLINICAL-TRIAL; SUPPLEMENTAL ASCORBATE; SUPPORTIVE TREATMENT; INDUCED CYTOTOXICITY; SURVIVAL TIMES; NANOPARTICLES; OXIDASE; ACID; GROWTH;

D O I：

10.1038/s41467-018-07257-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Intravenous pharmacological dose of ascorbate has been proposed as a potential antitumor therapy; however, its therapeutic efficacy is limited due to the slow autoxidation. Here, we report that palladium (Pd) nanocrystals, which possess intrinsic oxidase-like activity, accelerate the autoxidation of ascorbate, leading to the enhancement of its antitumor efficacy. The oxidase-like activity of Pd nanocrystals was facet-dependent, with the concave nanostructure enclosed by high-index facets catalyzing ascorbate autoxidation more efficiently than the planar nanostructure enclosed by low-index facets. Our first-principles calculations provide the underlying molecular mechanisms for the facet-dependent activation of O-2 molecule and subsequent ascorbate oxidation. Further in vitro and in vivo assays demonstrate the enhancement of the antitumor efficacy of ascorbate with these Pd concave nanocubes. Our animal experiments also indicate the combined approach with both ascorbate and Pd concave nanocubes displays an even better efficacy than currently available clinical medicines, with no obvious cytotoxicity to normal cells.

引用

页数：10

共 40 条

[1] SUPPLEMENTAL ASCORBATE IN SUPPORTIVE TREATMENT OF CANCER - PROLONGATION OF SURVIVAL TIMES IN TERMINAL HUMAN CANCER .1. [J].