Stereoselective synthesis of 2-(α-hydroxyalkyl)benzimidazoles

被引：20

作者：

Katritzky, AR ^{[1
]}

Aslan, DC ^{[1
]}

Oniciu, DC ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 13期

关键词：

D O I：

10.1016/S0957-4166(98)00202-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Lithiated oxazolo[3,4-a]benzimidazole 4 reacted with various alkyl halides to give oxazolo[3,4-a]benzimidazoles 5a-d in good yields as single diastereoisomers. (R)-Benzimidazol-2-y1 carbinols 6a-d were obtained upon hydrolysis under acidic conditions of 1H,3H-oxazolo[3,4-a]benzimidazole derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2245 / 2251

页数：7

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