Pazopanib for the treatment of renal cell carcinoma

被引：16

作者：

Welsh, Sarah J. ^{[1
]}

Fife, Kate ^{[1
]}

机构：

[1] Cambridge Univ Hosp NHS Fdn Trust, Cambridge CB2 0QQ, England

来源：

FUTURE ONCOLOGY | 2015年 / 11卷 / 08期

关键词：

antiangiogenic; kidney; pazopanib; renal cancer; treatment; tyrosine kinase inhibitor; DOUBLE-BLIND; PHASE-III; TARGETED THERAPIES; SUNITINIB; SAFETY; EFFICACY; TRIAL;

D O I：

10.2217/fon.14.274

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The incidence and mortality from renal cell cancer (RCC) is increasing. RCC tumors are particularly vascular in nature as a result of disruption of the VHL gene and/or its upstream pathway leading to upregulation of the hypoxia-inducible factor transcription factor. The hypoxia-inducible factor pathway drives angiogenesis by upregulating VEGF and bFGF, amongst other proangiogenic downstream target genes. Therapies which target angiogenesis have been successful in treating metastatic RCC (mRCC) and the receptor tyrosine kinase inhibitor, pazopanib, is licensed for first line treatment of mRCC. This review details the past, current and future roles of pazopanib in the treatment of mRCC.

引用

页码：1169 / 1179

页数：11

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