Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry

被引：125
|
作者：
Santa, Tomofumi [1 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
来源：
BIOMEDICAL CHROMATOGRAPHY | 2011年 / 25卷 / 1-2期
关键词：
derivatization; chromatography; electrospray; tandem mass spectrometry; HIGHLY SENSITIVE QUANTIFICATION; DANSYL CHLORIDE DERIVATIZATION; RAPID SCREENING-PROCEDURE; CHAIN FATTY-ACIDS; DRIED BLOOD SPOTS; LC-MS/MS METHOD; ELECTROSPRAY-IONIZATION; AMINO-ACIDS; CHEMICAL DERIVATIZATION; PRECOLUMN DERIVATIZATION;
D O I：
10.1002/bmc.1548
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) is one of the most prominent analytical techniques owing to its inherent selectivity and sensitivity. In LC/ESI-MS/MS, chemical derivatization is often used to enhance the detection sensitivity. Derivatization improves the chromatographic separation, and enhances the mass spectrometric ionization efficiency and MS/MS detectability. In this review, an overview of the derivatization reagents which have been applied to LC/ESI-MS/MS is presented, focusing on the applications to low molecular weight compounds. Copyright (C) 2010 John Wiley & Sons, Ltd.
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页码：1 / 10
页数：10
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