Microbial Toll/interleukin 1 receptor proteins: A new class of virulence factors

被引：19

作者：

Cirl, Christine ^{[1
]}

Miethke, Thomas ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Med Mikrobiol Immunol & Hyg, D-81675 Munich, Germany

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2010年 / 300卷 / 06期

关键词：

Toll-like receptor; Microbial Toll/interleukin 1 receptor proteins; Innate immune system; Pathogens; Virulence; UROPATHOGENIC ESCHERICHIA-COLI; VACCINIA VIRUS; INFECTION; MICE; FAMILY; TLR4; A52R; A46R;

D O I：

10.1016/j.ijmm.2010.04.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Quite a number of microbes possess genes which encode for proteins containing a Toll/interleukin 1 receptor domain. This domain is key for the physical interaction of eukaryotic Toll-like receptors with their adaptor molecules like MyD88 enabling innate immune cells to recognize invading pathogens and to initiate appropriate defense responses. Recent findings imply that microbial Toll/interleukin 1 receptor proteins impair Toll-like receptor signaling. As a consequence, secretion of pro-inflammatory cytokines is dampened, and microbial replication is enhanced. This group of proteins can thus be classified as a new family of virulence factors able to modulate the Toll-like receptor signaling cascade. This review summarizes current knowledge of the biology of this fascinating group of molecules. (C) 2010 Elsevier GmbH. All rights reserved.

引用

页码：396 / 401

页数：6

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