DNAM-1 Expression Marks an Alternative Program of NK Cell Maturation

被引：99

作者：

Martinet, Ludovic ^{[1
,2
]}

De Andrade, Lucas Ferrari ^{[1
,3
]}

Guillerey, Camille ^{[1
]}

Lee, Jason S. ^{[4
]}

Liu, Jing ^{[1
]}

Souza-Fonseca-Guimaraes, Fernando ^{[1
]}

Hutchinson, Dana S. ^{[5
]}

Kolesnik, Tatiana B. ^{[6
,7
]}

Nicholson, Sandra E. ^{[6
,7
]}

Huntington, Nicholas D. ^{[6
,7
]}

Smyth, Mark J. ^{[1
,8
]}

机构：

[1] QIMR Berghofer Med Res Inst, Immunol Canc & Infect Lab, Herston, Qld 4006, Australia

[2] Canc Res Ctr Toulouse, UMR 1037, INSERM, F-31000 Toulouse, France

[3] Univ Fed Parana, Celulas Inflamatorias & Neoplasicas Grp, BR-81530001 Curitiba, Parana, Brazil

[4] QIMR Berghofer Med Res Inst, Control Gene Express Lab, Herston, Qld 4006, Australia

[5] Monash Univ, Monash Inst Pharmaceut, Drug Discovery Biol, Dept Pharmacol,Sci, Parkville, Vic 3052, Australia

[6] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[7] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia

[8] Univ Queensland, Sch Med, Herston, Qld 4006, Australia

来源：

CELL REPORTS | 2015年 / 11卷 / 01期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

NATURAL-KILLER-CELLS; IL-15; TRANS-PRESENTATION; T-CELLS; IN-VIVO; DENDRITIC CELLS; ANTITUMOR IMMUNITY; RECEPTOR CD226; LYMPHOID-CELLS; NECTIN-2; CD112; MOLECULE;

D O I：

10.1016/j.celrep.2015.03.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling and functional studies that the activating receptor DNAM-1 (CD226) identifies two distinct NK cell functional subsets: DNAM-1(+) and DNAM-1(-) NK cells. DNAM-1(+) NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1(-) NK cells that differentiate from DNAM-1(+) NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.

引用

页码：85 / 97

页数：13

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