Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV

被引：88
作者：
de Jesus, O
Smith, PR
Spender, LC
Karstegl, CE
Niller, HH
Huang, D
Farrell, PJ
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Ludwig Inst Canc Res, London W2 1PG, England
[2] Univ Regensburg, Inst Med Mikrobiol & Hyg, D-93053 Regensburg, Germany
[3] Chinese Univ Hong Kong, Sir YK Pao Ctr Canc, Dept Clin Oncol, Shatin, Hong Kong, Peoples R China
来源：
JOURNAL OF GENERAL VIROLOGY | 2003年 / 84卷
关键词：
D O I：
10.1099/vir.0.19054-0
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Two sequences required for activity of the Epstein-Barr virus BART RNA promoter in transfection assays have been identified by site-directed mutagenesis. One contains a consensus AP-1 site; the other has some similarity to Ets and Stat consensus binding sites. Candidate sequences were suggested by mapping a region of unmethylated DNA in EBV around the BART promoter followed by in vivo footprinting the promoter in the C666-1 nasopharyngeal carcinoma cell line, which expresses BART RNAs. The data are presented in the context of a revised EBV DNA sequence, known as EBV wt, that is proposed as a future standard sequence for EBV.
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页码：1443 / 1450
页数：8
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