REMOVAL OF HIGH-FAT DIET AFTER CHRONIC EXPOSURE DRIVES BINGE BEHAVIOR AND DOPAMINERGIC DYSREGULATION IN FEMALE MICE

被引:50
作者
Carlin, Jesse L. [1 ]
McKee, Sarah E. [1 ]
Hill-Smith, Tiffany [2 ]
Grissom, Nicola M. [3 ]
George, Robert [1 ]
Lucki, Irwin [1 ,2 ]
Reyes, Teresa M. [1 ,3 ]
机构
[1] Univ Penn, Dept Pharmacol, Perelman Sch Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA
[3] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, 2120 East Galbraith Rd,A-129, Cincinnati, OH 45237 USA
关键词
dopamine; high-fat diet; sex difference; reward; binge; adolescence; DIFFERENTIAL SACCHARIN INTAKE; INDUCED OBESITY; NUCLEUS-ACCUMBENS; MESOLIMBIC DOPAMINE; EATING DISORDER; GENE-EXPRESSION; SEX-DIFFERENCES; PALATABLE FOOD; D2; RECEPTOR; RATS;
D O I
10.1016/j.neuroscience.2016.04.002
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A significant contributor to the obesity epidemic is the overconsumption of highly palatable, energy dense foods. Chronic intake of palatable foods is associated with neuroadaptations within the mesocorticolimbic dopamine system adaptations which may lead to behavioral changes, such as overconsumption or bingeing. We examined behavioral and molecular outcomes in mice that were given chronic exposure to a high-fat diet (HFD; 12 weeks), with the onset of the diet either in adolescence or adulthood. To examine whether observed effects could be reversed upon removal of the HFD, animals were also studied 4 weeks after a return to chow feeding. Most notably, female mice, particularly those exposed to HFD starting in adolescence, demonstrated the emergence of binge-like behavior when given restricted access to a palatable food. Further, changes in dopamine-related gene expression and dopamine content in the prefrontal cortex were observed. Some of these HFDdriven phenotypes reversed upon removal of the diet, whereas others were initiated by removal of the diet. These findings have implications for obesity management and interventions, as both pharmacological and behavioral therapies are often combined with dietary interventions (e.g., reduction in calorie dense foods). (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:170 / 179
页数:10
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