Antioxidant and antimicrobial evaluation of carboxymethylated and hydroxamated degraded polysaccharides from Sargassum fusiforrne

被引：72

作者：

Li, Yin-Ting ^{[1
]}

Chen, Bing-Jie ^{[1
,2
]}

Wu, Wei-Du ^{[3
]}

Ge, Kun ^{[4
]}

Wei, Xiao-Yi ^{[5
]}

Kong, Li-Min ^{[1
]}

Xie, Yuan-Yuan ^{[6
]}

Gu, Jin-Ping ^{[6
]}

Zhang, Jin-Chao ^{[4
]}

Zhou, Tao ^{[1
]}

机构：

[1] Zhejiang Gongshang Univ, Sch Food Sci & Biotechnol, 18 Xuezheng St, Hangzhou 310018, Zhejiang, Peoples R China

[2] Shanghai Acad Agr Sci, 1000 Jinqi Rd, Shanghai 201403, Peoples R China

[3] Hangzhou Wahaha Grp Co Ltd, Inst Food Sci, Ave 14, Hangzhou 310018, Zhejiang, Peoples R China

[4] Hebei Univ, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Hebei, Peoples R China

[5] Shanghai Business Sch, Fac Hospitality Management, Dept Food Sci, Shanghai 200235, Peoples R China

[6] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 118卷

基金：

国家重点研发计划;

关键词：

Polysaccharide from Satgassum fustforme; Antioxidant activity; Antimicrobial activity; ENTEROMORPHA-PROLIFERA; IN-VITRO; SULFATED POLYSACCHARIDE; INHIBITORY-ACTIVITIES; BIOLOGICAL-PROPERTIES; PURIFICATION; SEAWEED; IRON; PRESERVATION; EXTRACTION;

D O I：

10.1016/j.ijbiomac.2018.06.196

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to improve the bioactivity of the polysaccharide from Sargassum fusiforme (PSF), the degraded polysaccharide (DPSF) was modified by carboxymethylation, yielding carboxymethylated degraded polysaccharides (CDPSF), which were further modified to generate hydroxamated derivatives (HCDPSF). Both CDPSF and HCDPSF were characterized by Fourier transform infrared spectroscopy. The molecular weight of CDPSF and HCDPSF was found to be 354 kDa and 375 kDa, respectively. The in vitro antioxidant activity of CDPSF and HCDPSF was evaluated by determining the radical scavenging ability and total antioxidant activity. The results indicated that the antioxidant activity of CDPSF and HCDPSF was significantly improved when compared to those of DPSF. Antimicrobial assays indicated that both CDPSF and HCDPSF possessed a marked antimicrobial ability, while DPSF did not exhibit such effects under the same conditions. Such polysaccharide derivatives have potentials in the pharmaceutical and food industries. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：1550 / 1557

页数：8

共 37 条

[1] Synthesis of iron-crosslinked chitosan succinate and iron-crosslinked hydroxamated chitosan succinate and their in vitro evaluation as potential matrix materials for oral theophylline sustained-release beads [J].