Bilateral cerebral hemispheric infarction associated with sildenafil citrate (Viagra®) use

被引：15

作者：

Kim, K. -K. ^{[1
]}

Kim, D. G. ^{[1
]}

Ku, Y. H. ^{[1
]}

Lee, Y. J. ^{[2
]}

Kim, W. -C. ^{[1
]}

Kim, O. J. ^{[1
]}

Kim, H. S. ^{[1
]}

机构：

[1] Pochon CHA Univ, Coll Med, Dept Neurol, Songnam, Gyeunggido, South Korea

[2] Pochon CHA Univ, Coll Med, Dept Radiol, Songnam, Gyeunggido, South Korea

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2008年 / 15卷 / 03期

关键词：

cardioembolism; cerebral infarction; sildenafil;

D O I：

10.1111/j.1468-1331.2007.02025.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sildenafil citrate (Viagra((R))) is one of the frequently prescribed drugs for men with erectile dysfunction. We describe a 52-year-old man with bilateral middle cerebral artery (MCA) territory infarction after sildenafil use. He ingested 100 mg of sildenafil and about 1 h later, he complained of chest discomfort, palpitation and dizziness followed by mental obtundation, global aphasia and left hemiparesis. Brain magnetic resonance imaging documented acute bilateral hemispheric infarction, and cerebral angiography showed occluded bilateral MCA. Despite significant bilateral MCA stenosis and cerebral infarction, systemic hypotension persisted for a day. We presume that cerebral infarction was caused by cardioembolism with sildenafil use.

引用

页码：306 / 308

页数：3

共 16 条

[1] Acute, symptomatic atrial fibrillation after sildenafil citrate therapy in a patient with hypertrophic obstructive cardiomyopathy [J].

Awan, GM ;

Calderon, E ;

Dawood, G ;

Alpert, MA .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2000, 320 (01) :69-71

[2] CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES - FUNCTIONAL IMPLICATIONS OF MULTIPLE ISOFORMS [J].

BEAVO, JA .

PHYSIOLOGICAL REVIEWS, 1995, 75 (04) :725-748

[3] Use of sildenafil (Viagra) in patients with cardiovascular disease [J].

Cheitlin, MD ;

Hutter, AM ;

Brindis, RG ;

Ganz, P ;

Kaul, S ;

Russell, RO ;

Zusman, RM ;

Forrester, JS ;

Douglas, PS ;

Faxon, DP ;

Fisher, JD ;

Gibbons, RJ ;

Halperin, JL ;

Hutter, AM ;

Hochman, JS ;

Kaul, S ;

Weintraub, WS ;

Winters, WL ;

Wolk, MJ .

CIRCULATION, 1999, 99 (01) :168-177

[4]

Egan RA, 2002, NEUROLOGY, V59, P293, DOI 10.1212/WNL.59.2.293-a

[5] Oral sildenafil in the treatment of erectile dysfunction [J].

Goldstein, I ;

Lue, TF ;

Padma-Nathan, H ;

Rosen, RC ;

Steers, WD ;

Wicker, PA .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (20) :1397-1404

[6] Stroke - An adverse reaction to sildenafil [J].

Habek, M ;

Petravic, D .

CLINICAL NEUROPHARMACOLOGY, 2006, 29 (03) :165-167

[7] Aroused to atrial fibrillation? [J].

Hahn, IH ;

Hoffman, RS .

AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2000, 18 (05) :642-642

[8] Atrial fibrillation and continuous hypotension induced by sildenafil in an intermittent WPW syndrome patient [J].

Hayashi, K ;

Minezaki, KK ;

Narukawa, M ;

Ookubo, M ;

Mitsuhashi, T ;

Shimada, K .

JAPANESE HEART JOURNAL, 1999, 40 (06) :827-830

[9]

Koner RA, 2000, AM J MED, V19, p13S

[10] The clinical safety of Viagra [J].

Lim, PHC ;

Moorthy, P ;

Benton, KGF .

NITRIC OXIDE: NOVEL ACTIONS, DELETERIOUS EFFECTS AND CLINICAL POTENTIAL, 2002, 962 :378-388

← 1 2 →