Adriamycin nephropathy: A model of focal segmental glomerulosclerosis

被引：347
作者：
Lee, Vincent W. S. [1 ]
Harris, David C. H. [1 ]
机构：
[1] Univ Sydney, Ctr Transplant & Renal Res, Westmead Millennium Inst, Westmead Hosp, Sydney, NSW 2006, Australia
来源：
NEPHROLOGY | 2011年 / 16卷 / 01期
基金：
英国医学研究理事会;
关键词：
animal model; chronic kidney failure; doxorubicin; focal segmental glomerulosclerosis; macrophage; REGULATORY T-CELLS; RENAL INJURY; PODOCYTE INJURY; DOXORUBICIN HYDROCHLORIDE; PROTEINURIC RATS; DENDRITIC CELLS; KIDNEY-DISEASE; C57BL/6; MICE; SUSCEPTIBILITY; MACROPHAGES;
D O I：
10.1111/j.1440-1797.2010.01383.x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Adriamycin nephropathy (AN) is a rodent model of chronic kidney disease that has been studied extensively and has enabled a greater understanding of the processes underlying the progression of chronic proteinuric renal disease. AN is characterized by podocyte injury followed by glomerulosclerosis, tubulointerstitial inflammation and fibrosis. Genetic studies have demonstrated a number of loci that alter both risk and severity of renal injury induced by Adriamycin. Adriamycin-induced renal injury has been shown in numerous studies to be modulated by both non-immune and immune factors, and has facilitated further study of mechanisms of tubulointerstitial injury. This review will outline the pharmacological behaviour of Adriamycin, and describe in detail the model of AN, including its key structural characteristics, genetic susceptibility and pathogenesis.
引用
收藏
页码：30 / 38
页数：9
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