Adriamycin nephropathy: A model of focal segmental glomerulosclerosis

被引：360
作者：
Lee, Vincent W. S. [1 ]
Harris, David C. H. [1 ]
机构：
[1] Univ Sydney, Ctr Transplant & Renal Res, Westmead Millennium Inst, Westmead Hosp, Sydney, NSW 2006, Australia
来源：
NEPHROLOGY | 2011年 / 16卷 / 01期
基金：
英国医学研究理事会;
关键词：
animal model; chronic kidney failure; doxorubicin; focal segmental glomerulosclerosis; macrophage; REGULATORY T-CELLS; RENAL INJURY; PODOCYTE INJURY; DOXORUBICIN HYDROCHLORIDE; PROTEINURIC RATS; DENDRITIC CELLS; KIDNEY-DISEASE; C57BL/6; MICE; SUSCEPTIBILITY; MACROPHAGES;
D O I：
10.1111/j.1440-1797.2010.01383.x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Adriamycin nephropathy (AN) is a rodent model of chronic kidney disease that has been studied extensively and has enabled a greater understanding of the processes underlying the progression of chronic proteinuric renal disease. AN is characterized by podocyte injury followed by glomerulosclerosis, tubulointerstitial inflammation and fibrosis. Genetic studies have demonstrated a number of loci that alter both risk and severity of renal injury induced by Adriamycin. Adriamycin-induced renal injury has been shown in numerous studies to be modulated by both non-immune and immune factors, and has facilitated further study of mechanisms of tubulointerstitial injury. This review will outline the pharmacological behaviour of Adriamycin, and describe in detail the model of AN, including its key structural characteristics, genetic susceptibility and pathogenesis.
引用
收藏
页码：30 / 38
页数：9
相关论文
共 65 条
[1]   ADRIAMYCIN AFFECTS GLOMERULAR RENAL-FUNCTION - EVIDENCE FOR THE INVOLVEMENT OF OXYGEN RADICALS [J].
BARBEY, MM ;
FELS, LM ;
SOOSE, M ;
POELSTRA, K ;
GWINNER, W ;
BAKKER, W ;
STOLTE, H .
FREE RADICAL RESEARCH COMMUNICATIONS, 1989, 7 (3-6) :195-203
[2]  
Bucciarelli E, 1976, Lav Ist Anat Istol Patol Univ Studi Perugia, V36, P53
[3]   DOXORUBICIN HYDROCHLORIDE-ASSOCIATED RENAL-FAILURE [J].
BURKE, JF ;
LAUCIUS, JF ;
BRODOVSKY, HS ;
SORIANO, RZ .
ARCHIVES OF INTERNAL MEDICINE, 1977, 137 (03) :385-388
[4]   IL-10/TGF-β-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis [J].
Cao, Qi ;
Wang, Yiping ;
Zheng, Dong ;
Sun, Yan ;
Wang, Ya ;
Lee, Vincent W. S. ;
Zheng, Guoping ;
Tan, Thian Kui ;
Ince, Jon ;
Alexander, Stephen I. ;
Harris, David C. H. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 21 (06) :933-942
[5]   Experimental focal segmental glomerulosclerosis in mice [J].
Chen, A ;
Sheu, LF ;
Ho, YS ;
Lin, YF ;
Chou, WY ;
Chou, TC ;
Lee, WH .
NEPHRON, 1998, 78 (04) :440-452
[6]   Protective effect of sulodexide on podocyte injury in adriamycin nephropathy rats [J].
Chen, Shan ;
Fang, Zhan ;
Zhu, Zhonghua ;
Deng, Anguo ;
Liu, Jianshe ;
Zhang, Chun .
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2009, 29 (06) :715-719
[7]   BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25- responder T cells than C57BL/6 mice [J].
Chen, X ;
Oppenheim, JJ ;
Howard, OMZ .
JOURNAL OF LEUKOCYTE BIOLOGY, 2005, 78 (01) :114-121
[8]   Distinct Roles for Basal and Induced COX-2 in Podocyte Injury [J].
Cheng, Huifang ;
Fan, Xiaofeng ;
Guan, Youfei ;
Moeckel, Gilbert W. ;
Zent, Roy ;
Harris, Raymond C. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (09) :1953-1962
[9]   Effects of Vitamin D3 (Cholecalciferol) on Adriamycin-Induced Nephrotoxicity [J].
Dabak, Durrin Ozlem ;
Kuloglu, Tuncay ;
Ozercan, Mehmet Resat .
RENAL FAILURE, 2009, 31 (05) :400-405
[10]   Wnt/β-Catenin Signaling Promotes Podocyte Dysfunction and Albuminuria [J].
Dai, Chunsun ;
Stolz, Donna B. ;
Kiss, Lawrence P. ;
Monga, Satdarshan P. ;
Holzman, Lawrence B. ;
Liu, Youhua .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (09) :1997-2008
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