Large granular lymphocytic leukaemia after solid organ and haematopoietic stem cell transplantation

被引：11

作者：

Awada, Hassan ^{[1
]}

Mahfouz, Reda Z. ^{[1
]}

Durrani, Jibran ^{[1
]}

Kishtagari, Ashwin ^{[1
]}

Jagadeesh, Deepa ^{[2
]}

Lichtin, Alan E. ^{[3
]}

Hill, Brian T. ^{[2
]}

Hamilton, Betty K. ^{[4
]}

Carraway, Hetty E. ^{[5
]}

Nazha, Aziz ^{[5
]}

Majhail, Navneet S. ^{[4
]}

Sobecks, Ronald ^{[3
]}

Visconte, Valeria ^{[1
]}

Kalaycio, Matt ^{[3
]}

Sekeres, Mikkael A. ^{[5
]}

Maciejewski, Jaroslaw P. ^{[1
]}

机构：

[1] Cleveland Clin, Taussig Canc Inst, Dept Translat Hematol & Oncol Res, Cleveland, OH 44106 USA

[2] Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Lymphoid Malignancies Program, Cleveland, OH 44106 USA

[3] Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Cleveland, OH 44106 USA

[4] Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA

[5] Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Leukaemia Program, Cleveland, OH 44106 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2020年 / 189卷 / 02期

关键词：

large granular lymphocytic leukaemia; solid organ transplantation; bone marrow transplantation; EXPANSION; MUTATIONS; FEATURES;

D O I：

10.1111/bjh.16336

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

T-cell large granular lymphocytic leukaemia (T-LGLL) is a chronic clonal lymphoproliferative disorder of cytotoxic T lymphocytes which commonly occurs in older patients and is often associated with autoimmune diseases. Among 246 patients with T-LGLL seen at our institution over the last 10 years, we encountered 15 cases following solid organ or haematopoietic stem cell transplantation. Here, we studied the clinical characterization of these cases and compared them to de novo T-LGLL. This experience represented a clear picture of the intricate nature of the disease manifestation and the complexities of several immune mechanisms triggering the clonal expansion.

引用

页码：318 / 322

页数：5

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