Essential thrombocythemia: Baseline characteristics and risk factors for survival and thrombosis in a series of 214 patients

被引：6
作者：
Angona, Anna [1 ,2 ,3 ]
Alvarez-Larran, Alberto [1 ,2 ,3 ]
Bellosillo, Beatriz [3 ,4 ,5 ]
Martinez-Aviles, Luz [2 ,3 ,4 ]
Garcia-Pallarols, Francesc [1 ,3 ]
Longaron, Raquel [3 ,4 ]
Ancochea, Agueda [1 ,2 ,3 ]
Besses, Caries [1 ,3 ]
机构：
[1] Hosp del Mar, IMIM, Serv Hematol, Barcelona, Spain
[2] Univ Autonoma Barcelona, E-08193 Barcelona, Spain
[3] Hosp del Mar, IMIM, Grp Recerca Clin Aplicada Neoplasies Hematol, Barcelona, Spain
[4] Hosp del Mar, IMIM, Serv Patol, Barcelona, Spain
[5] Univ Pompeu Fabra, Barcelona, Spain
来源：
MEDICINA CLINICA | 2015年 / 144卷 / 06期
关键词：
Essential thrombocythemia; Thrombosis; Survival; JAK2V617F; Calreticulin; JAK2 V617F MUTATION; POLYCYTHEMIA-VERA; MYELOPROLIFERATIVE NEOPLASMS; DIAGNOSTIC-CRITERIA; COMPLICATIONS; LEUKOCYTOSIS; MYELOFIBROSIS; CALRETICULIN;
D O I：
10.1016/j.medcli.2014.04.029
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background and objective: Two prognostic models to predict overall survival and thrombosis-free survival have been proposed: International Prognostic Score for Essential Thrombocythemia (IPSET) and IPSET-Thrombosis, respectively, based on age, leukocytes count, history of previous thrombosis, the presence of cardiovascular risk factors and the JAK2 mutational status. The aim of the present study was to assess the clinical and biological characteristics at diagnosis and during evolution in essential thrombocythemia (ET) patients as well as the factors associated with survival and thrombosis and the usefulness of these new prognostic models. Patients and methods: We have evaluated the clinical data and the mutation status of JAK2. MPL and calreticulin of 214 ET patients diagnosed in a single center between 1985 and 2012, classified according to classical risk stratification, IPSET and IPSET-Thrombosis. Results: With a median follow-up of 6.9 years, overall survival was not associated with any variable by multivariate analysis. Thrombotic history and leukocytes > 10 x 10(9)/l were associated with thrombosis-free survival (TFS). In our series, IPSET prognostic systems of survival and thrombosis did not provide more clinically relevant information regarding the classic risk of thrombosis stratification. Conclusion: Thrombotic history and leukocytosis > 10 x 10(9)/l were significantly associated with lower TFS, while the prognostic IPSET-Thrombosis system did not provide more information than classical thrombotic risk assessment. (C) 2014 Elsevier Espana, S.L.U. All rights reserved.
引用
收藏
页码：247 / 253
页数：7
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