Factors that impact pharmacokinetic measurements of antibody therapeutics: what is your PK assay telling you?

被引：3
作者：
Fischer, Saloumeh Kadkhodayan [1 ]
机构：
[1] Genentech Inc, Assay Dev & Technol, 1 DNA Way, San Francisco, CA 94080 USA
来源：
BIOANALYSIS | 2017年 / 9卷 / 20期
关键词：
free drug; LBA; ligand binding assay; pharmacokinetics; PK; total drug; DRUG QUANTIFICATION; BEVACIZUMAB; VALIDATION; MODEL;
D O I：
10.4155/bio-2017-0173
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
""... assay reagents, format and conditions can significantly impact the PK parameters/profiles for an antibody therapeutic depending on what drug species is being detected.""
引用
收藏
页码：1531 / 1533
页数：3
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