Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults - United States, March-July 2021

被引：167

作者：

Tenforde, Mark W. ^{[1
]}

Self, Wesley H. ^{[2
]}

Naioti, Eric A. ^{[1
]}

Ginde, Adit A. ^{[3
]}

Douin, David J. ^{[3
]}

Olson, Samantha M. ^{[1
]}

Talbot, H. Keipp ^{[2
]}

Casey, Jonathan D. ^{[2
]}

Mohr, Nicholas M. ^{[4
]}

Zepeski, Anne ^{[4
]}

Gaglani, Manjusha ^{[5
,6
]}

McNeal, Tresa ^{[5
]}

Ghamande, Shekhar ^{[5
]}

Shapiro, Nathan I. ^{[7
]}

Gibbs, Kevin W. ^{[8
]}

Files, D. Clark ^{[8
]}

Hager, David N. ^{[9
]}

Shehu, Arber ^{[9
]}

Prekker, Matthew E. ^{[10
]}

Erickson, Heidi L. ^{[10
]}

Gong, Michelle N. ^{[11
]}

Mohamed, Amira ^{[11
]}

Henning, Daniel J. ^{[12
]}

Steingrub, Jay S. ^{[13
]}

Peltan, Ithan D. ^{[14
,15
]}

Brown, Samuel M. ^{[14
,15
]}

Martin, Emily T. ^{[16
]}

Monto, Arnold S. ^{[16
]}

Khan, Akram ^{[17
]}

Hough, Catherine L. ^{[17
]}

Busse, Laurence W. ^{[18
]}

ten Lohuis, Caitlin C. ^{[18
]}

Duggal, Abhijit ^{[19
]}

Wilson, Jennifer G. ^{[20
]}

Gordon, Alexandra June ^{[20
]}

Qadir, Nida ^{[21
]}

Chang, Steven Y. ^{[21
]}

Mallow, Christopher ^{[22
]}

Rivas, Carolina ^{[22
]}

Babcock, Hilary M. ^{[23
]}

Kwon, Jennie H. ^{[23
]}

Exline, Matthew C. ^{[24
]}

Halasa, Natasha ^{[2
]}

Chappell, James D. ^{[2
]}

Lauring, Adam S. ^{[25
]}

Grijalva, Carlos G. ^{[2
]}

Rice, Todd W. ^{[2
]}

Jones, Ian D. ^{[2
]}

Stubblefield, William B. ^{[2
]}

Baughman, Adrienne ^{[2
]}

机构：

[1] CDC, COVID 19 Response Team, Atlanta, GA 30333 USA

[2] Vanderbilt Univ, Med Ctr, Nashville, TN USA

[3] Univ Colorado, Sch Med, Aurora, CO USA

[4] Univ Iowa, Iowa City, IA USA

[5] Baylor Scott & White Hlth, Temple, TX USA

[6] Texas A&M Univ, Coll Med, Temple, TX 76508 USA

[7] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[8] Wake Forest Univ, Baptist Med Ctr, Winston Salem, NC 27101 USA

[9] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA

[10] Hennepin Cty Med Ctr, Minneapolis, MN 55415 USA

[11] Albert Einstein Coll Med, Montefiore Healthcare Ctr, Bronx, NY 10467 USA

[12] Univ Washington, Sch Med, Seattle, WA USA

[13] Baystate Med Ctr, Springfield, MA USA

[14] Intermt Med Ctr, Salt Lake City, UT USA

[15] Univ Utah, Salt Lake City, UT USA

[16] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA

[17] Oregon Hlth & Sci Univ Hosp, Portland, OR USA

[18] Emory Univ, Sch Med, Atlanta, GA USA

[19] Cleveland Clin, Cleveland, OH 44106 USA

[20] Stanford Univ, Sch Med, Palo Alto, CA 94304 USA

[21] Ronald Reagan UCLA Med Ctr, Los Angeles, CA USA

[22] Univ Miami, Miami, FL USA

[23] Washington Univ, St Louis, MO 63110 USA

[24] Ohio State Univ, Wexner Med Ctr, Columbus, OH 43210 USA

[25] Univ Michigan, Sch Med, Ann Arbor, MI USA

来源：

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT | 2021年 / 70卷 / 34期

关键词：

D O I：

10.15585/mmwr.mm7034e2

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

What is already known about this topic? COVID-19 mRNA vaccines provide strong protection against severe COVID-19; however, the duration of protection is uncertain. What is added by this report? Among 1,129 patients who received 2 doses of a mRNA vaccine, no decline in vaccine effectiveness against COVID-19 hospitalization was observed over 24 weeks. Vaccine effectiveness was 86% 2-12 weeks after vaccination and 84% at 13-24 weeks. Vaccine effectiveness was sustained among groups at risk for severe COVID-19. What are the implications for public health practice? mRNA vaccine effectiveness against COVID-19-associated hospitalizations was sustained over 24 weeks; ongoing monitoring is needed as new SARS- CoV-2 variants emerge. To reduce hospitalization, all eligible persons should be offered COVID-19 vaccination.

引用

页码：1156 / 1162

页数：7

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