Molecular cloning of a novel basic helix-loop-helix protein from the rat brain

被引：41
作者：
Kume, H
Maruyama, K
Tomita, T
Iwatsubo, T
Saido, TC
Obata, K
机构：
[1] UNIV TOKYO,FAC PHARMACEUT SCI,TOKYO 113,JAPAN
[2] TOKYO METROPOLITAN INST MED SCI,TOKYO 113,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 219卷 / 02期
关键词：
D O I：
10.1006/bbrc.1996.0267
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the mammalian nervous system, several basic helix-loop-helix (bHLH) proteins have been identified that may play essential roles in neurogenesis or neural development. This paper describes a novel bHLH protein in rat brain, which has a bHLH domain highly homologous with that of MATH-2 and NeuroD. On the other hand, the amino-acid sequence of the other regions had little homology with those of the known proteins. This protein consists of 381 amino acids and was detected only in neural tissue, indicating that it has an important role specific to neuronal activities. (C) 1996 Academic Press, Inc.
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页码：526 / 530
页数：5
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