AMP-activated protein kinase sparks the fire of cardioprotection against myocardial ischemia and cardiac ageing

被引：60
作者：
Gu, Chunhu [1 ,2 ]
Li, Tian [3 ]
Jiang, Shuai [4 ]
Yang, Zhi [3 ]
Lv, Jianjun [3 ]
Yi, Wei [2 ]
Yang, Yang [1 ]
Fang, Minfeng [1 ]
机构：
[1] Northwest Univ, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Fac Life Sci, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Cardiovasc Surg, 127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China
[3] Fourth Mil Med Univ, Sch Basic Med, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China
[4] Fourth Mil Med Univ, Dept Aerosp Med, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China
来源：
AGEING RESEARCH REVIEWS | 2018年 / 47卷
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
AMP-activated protein kinase; Myocardial ischemia; Cardiac ageing; Glucose metabolism; Mitochondrial biosynthesis; FATTY-ACID OXIDATION; AGE-RELATED INTOLERANCE; REPERFUSION INJURY; GLUCOSE-UPTAKE; ISCHEMIA/REPERFUSION INJURY; GLUT4; TRANSLOCATION; QUALITY-CONTROL; EMERGING ROLE; STRESS; HEART;
D O I：
10.1016/j.arr.2018.08.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
AMP-activated protein kinase (AMPK) is a pivotal regulator of some endogenous defensive molecules in various pathological processes, particularly myocardial ischemia (MI), a high risk of myocardial infarction. Thereby it is of great significance to explore the inherent mechanism between AMPK and myocardial infarction. In this review, we first introduce the structure and role of AMPK in the heart. Next, we introduce the mechanisms of AMPK in the heart; followed by the energy regulation of AMPK in MI. Lastly, the attention will be expanded to some potential directions and further perspectives. The information compiled here will be helpful for further research and drug design in the future before AMPK might be considered as a therapeutic target of MI.
引用
收藏
页码：168 / 175
页数：8
相关论文
共 123 条
[1]   Efficacy and Safety of a Novel Dual Modulator of Adenosine Triphosphate-Citrate Lyase and Adenosine Monophosphate-Activated Protein Kinase in Patients With Hypercholesterolemia [J].
Ballantyne, Christie M. ;
Davidson, Michael H. ;
MacDougall, Diane E. ;
Bays, Harold E. ;
DiCarlo, Lorenzo A. ;
Rosenberg, Noah L. ;
Margulies, Janice ;
Newton, Roger S. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (13) :1154-1162
[2]   Activation of cardiac hypertrophic signaling pathways in a transgenic mouse with the human PRKAG2 Thr400Asn mutation [J].
Banerjee, Sanjay K. ;
McGaffin, Kenneth R. ;
Huang, Xueyin N. ;
Ahmad, Ferhaan .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2010, 1802 (02) :284-291
[3]   The Role of PPARα in Metformin-Induced Attenuation of Mitochondrial Dysfunction in Acute Cardiac Ischemia/Reperfusion in Rats [J].
Barreto-Torres, Giselle ;
Parodi-Rullan, Rebecca ;
Javadov, Sabzali .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2012, 13 (06) :7694-7709
[4]   Mitochondrial and Metabolic Gene Expression in the Aged Rat Heart [J].
Barton, Gregory P. ;
Sepe, Joseph J. ;
McKieman, Susan H. ;
Aiken, Judd M. ;
Diffee, Gary M. .
FRONTIERS IN PHYSIOLOGY, 2016, 7
[5]   The structure of a domain common to archaebacteria and the homocystinuria disease protein [J].
Bateman, A .
TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (01) :12-13
[6]  
Benjamin EJ, 2018, CIRCULATION, V137, pE67, DOI [10.1161/CIR.0000000000000558, 10.1161/CIR.0000000000000485, 10.1161/CIR.0000000000000530]
[7]   Hypertension and aging [J].
Buford, Thomas W. .
AGEING RESEARCH REVIEWS, 2016, 26 :96-111
[8]   Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling [J].
Calvert, John W. ;
Gundewar, Susheel ;
Jha, Saurabh ;
Greer, James J. M. ;
Bestermann, William H. ;
Tian, Rong ;
Lefer, David J. .
DIABETES, 2008, 57 (03) :696-705
[9]   Sex differences in age-related changes in the sleep-wake cycle [J].
Carrier, Julie ;
Semba, Kazue ;
Deurveilher, Samuel ;
Drogos, Lauren ;
Cyr-Cronier, Jessica ;
Lord, Catherine ;
Sekerovick, Zoran .
FRONTIERS IN NEUROENDOCRINOLOGY, 2017, 47 :66-85
[10]   Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K-Akt signaling in diabetic rats [J].
Chen, Keke ;
Li, Guohua ;
Geng, Fenghao ;
Zhang, Zhao ;
Li, Jiani ;
Yang, Min ;
Dong, Ling ;
Gao, Feng .
APOPTOSIS, 2014, 19 (06) :946-957
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