STOX2 but not STOX1 is differentially expressed in decidua from pre-eclamptic women: data from the Second Nord-Trondelag Health Study

被引：23

作者：

Fenstad, M. H. ^{[1
]}

Johnson, M. P. ^{[2
]}

Loset, M. ^{[1
]}

Mundal, S. B. ^{[1
]}

Roten, L. T. ^{[1
]}

Eide, I. P. ^{[3
]}

Bjorge, L. ^{[4
]}

Sande, R. K. ^{[4
]}

Johansson, A. K. ^{[1
]}

Dyer, T. D. ^{[2
]}

Forsmo, S. ^{[5
]}

Blangero, J. ^{[2
]}

Moses, E. K. ^{[2
]}

Austgulen, R. ^{[1
]}

机构：

[1] Norwegian Univ Sci & Technol NTNU, Fac Med, Dept Canc Res & Mol Med, N-7006 Trondheim, Norway

[2] SW Fdn Biomed Res, Dept Genet, San Antonio, TX 78227 USA

[3] St Olavs Hosp, Dept Obstet & Gynecol, N-7006 Trondheim, Norway

[4] Haukeland Hosp, Dept Obstet & Gynecol, N-5021 Bergen, Norway

[5] NTNU, Fac Med, Dept Publ Hlth & Gen Practice, N-7006 Trondheim, Norway

来源：

MOLECULAR HUMAN REPRODUCTION | 2010年 / 16卷 / 12期

基金：

美国国家卫生研究院;

关键词：

intrauterine growth restriction (IUGR); decidua basalis; pre-eclampsia; HUNT2; STOX genes; MATERNAL SUSCEPTIBILITY LOCUS; FETAL-GROWTH RESTRICTION; GENOME-WIDE SCAN; GENE DUPLICATION; PREGNANCY; LINKAGE; RISK; RECURRENCE; COMPONENTS; EVOLUTION;

D O I：

10.1093/molehr/gaq064

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Variation in the Storkhead box-1 (STOX1) gene has previously been associated with pre-eclampsia. In this study, we assess candidate single nucleotide polymorphisms (SNPs) in STOX1 in an independent population cohort of pre-eclamptic (n = 1.139) and non-pre-eclamptic (n = 2.269) women (the HUNT2 study). We also compare gene expression levels of STOX1 and its paralogue, Storkhead box-2 (STOX2) in decidual tissue from pregnancies complicated by pre-eclampsia and/or fetal growth restriction (FGR) (n = 40) to expression levels in decidual tissue from uncomplicated pregnancies (n = 59). We cannot confirm association of the candidate SNPs to pre-eclampsia (P > 0.05). For STOX1, no differential gene expression was observed in any of the case groups, whereas STOX2 showed significantly lower expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls (P = 0.01). We further report a strong correlation between transcriptional alterations reported previously in choriocarcinoma cells over expressing STOX1A and alterations observed in decidual tissue of pre-eclamptic women with FGR.

引用

页码：960 / 968

页数：9

共 55 条

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