Poly (ADP-ribose) polymerase and brain ischemia

被引：0

作者：

Traystman, RJ ^{[1
]}

Kofler, J ^{[1
]}

Sawada, M ^{[1
]}

Martin, LJ ^{[1
]}

Dawson, VL ^{[1
]}

Hurn, PD ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Dept Anesthesiol Crit Care Med, Baltimore, MD 21287 USA

来源：

MOLECULAR MECHANISMS AND EPOCHAL THERAPEUTICS OF ISCHEMIC STROKE AND DEMENTIA | 2003年 / 1252卷

关键词：

focal ischemia; global ischemia; stroke; cardiac arrest/CPR; PARP; neuroprotection;

D O I：

10.1016/S0531-5131(03)00093-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Poly (ADP-ribose) polymerase (PARP-1) is a nuclear enzyme that facilitates DNA repair and may be important in neuronal cell death in a variety of diseases including cardiac arrest/cardiopulmonary resuscitation (CPR) and stroke. This chapter briefly reviews the characteristics of PARP, its activation, and its role in both focal (stroke) and global (cardiac arrest/CPR) cerebral ischemia. We demonstrate PARP deficiency to be effective in reducing neuronal reperfusion injury after stroke and cardiac arrest/CPR in mouse models. These data suggest a selective role of PARP-1 in glutamate excitotoxicity and that strategies of inhibiting PARP-1 may offer substantial neuroprotection in focal and global cerebral ischemia. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：21 / 29

页数：9

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