Preparation of cellulose-based chromatographic medium for biological separation: A review

被引：26
作者：
Yao, Tian [1 ]
Song, Jialing [1 ]
Gan, Ya [1 ]
Qiao, Liangzhi [2 ]
Du, Kaifeng [2 ]
机构：
[1] Chengdu Univ, Sichuan Engn & Technol Res Ctr Coarse Cereal Indus, Sch Food & Biol Engn, Key Lab Coarse Cereal Proc,Minist Agr & Rural Affa, Chengdu 610106, Peoples R China
[2] Sichuan Univ, Sch Chem Engn, Dept Pharmaceut & Biol Engn, Chengdu 610065, Peoples R China
来源：
JOURNAL OF CHROMATOGRAPHY A | 2022年 / 1677卷
关键词：
Cellulose; Emulsification; Chromatographic medium; Microspheres; VIRUS-LIKE PARTICLES; IONIC LIQUID; PROTEIN ADSORPTION; MICROCRYSTALLINE CELLULOSE; MEMBRANE CHROMATOGRAPHY; RAPID DISSOLUTION; CARBON NANOTUBES; POLYMER-CHAINS; MASS-TRANSFER; BEADS;
D O I：
10.1016/j.chroma.2022.463297
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Cellulose is a kind of renewable linear polysaccharide with good safety, hydrophilicity, biocompatibility and biodegradability and has become a commonly used chromatographic medium for biological separation and purification. The purpose of this paper is to describe the recent developments in the applications of cellulose-based absorbents as chromatographic medium. This review also attempts to explain the current situation of cellulose-based chromatographic medium from the aspects of cellulose dissolution, common strategies for generating spherical particles of cellulose and its derivatives (such as titration, emulsification, microfluidic and other synthesis methods) and improvement of adsorption properties. Furthermore, non-spherical cellulose-based chromatographic medium are also described briefly. (c) 2022 Elsevier B.V. All rights reserved.
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页数：16
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