Concomitant EML4-ALK rearrangement and EGFR mutation in non-small cell lung cancer patients: a literature review of 100 cases

被引：36

作者：

Lo Russo, Giuseppe ^{[1
]}

Imbimbo, Martina ^{[1
]}

Corrao, Giulia ^{[1
]}

Proto, Claudia ^{[1
]}

Signorelli, Diego ^{[1
]}

Vitali, Milena ^{[1
]}

Ganzinelli, Monica ^{[1
]}

Botta, Laura ^{[2
]}

Zilembo, Nicoletta ^{[1
]}

de Braud, Filippo ^{[1
]}

Garassino, Marina Chiara ^{[1
]}

机构：

[1] Ist Nazl Tumori, Fdn IRCCS, Dept Med Oncol, Milan, Italy

[2] Ist Nazl Tumori, Fdn IRCCS, Evaluat Epidemiol Unit, Dept Prevent & Predict Med, Milan, Italy

来源：

ONCOTARGET | 2017年 / 8卷 / 35期

关键词：

EML4-ALK rearrangements; EGFR mutations; non-small cell lung cancer; concomitant; coexistent; GROWTH-FACTOR-RECEPTOR; TYROSINE KINASE INHIBITORS; ALK REARRANGEMENT; FUSION GENE; BRAIN METASTASES; ADENOCARCINOMA; TRANSLOCATION; KRAS; NSCLC; SURVIVAL;

D O I：

10.18632/oncotarget.17431

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The discovery of EGFR mutations and EML4-ALK gene rearrangements has radically changed the therapeutic scenario for patients with advanced non-small cell lung cancer. ALK and EGFR tyrosine-kinase inhibitors showed better activity and efficacy than standard chemotherapy in the first and second line treatment settings, leading to a clear advantage in overall survival of advanced non-small cell lung cancer patients harboring these genetic alterations. Historically the coexistence of EGFR mutations and EML4-ALK rearrangements in the same tumor has been described as virtually impossible. Nevertheless many recent observations seem to show that it is not true in all cases. In this review we will discuss the available literature data regarding this rare group of patients in order to give some suggestions useful for their clinical management. Furthermore we report here two cases of concomitant presence of both alterations that will help us in the development of discussion.

引用

页码：59889 / 59900

页数：12

共 58 条

[1] Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial [J].

Andrews, DW ;

Scott, CB ;

Sperduto, PW ;

Flanders, AE ;

Gaspar, LE ;

Schell, MC ;

Werner-Wasik, M ;

Demas, W ;

Ryu, J ;

Bahary, JP ;

Souhami, L ;

Rotman, M ;

Mehta, MP ;

Curran, WJ .

LANCET, 2004, 363 (9422) :1665-1672

[2] Concomitant EGFR mutation and ALK rearrangement in lung adenocarcinoma is more frequent than expected: Report of a case and review of the literature with demonstration of genes alteration into the same tumor cells [J].

Baldi, Licia ;

Mengoli, Maria Cecilia ;

Bisagni, Alessandra ;

Banzi, Maria Chiara ;

Boni, Corrado ;

Rossi, Giulio .

LUNG CANCER, 2014, 86 (02) :291-295

[3] Parallel FISH and Immunohistochemical Studies of ALK Status in 3244 Non-Small-Cell Lung Cancers Reveal Major Discordances [J].

Cabillic, Florian ;

Gros, Audrey ;

Dugay, Frederic ;

Begueret, Hugues ;

Mesturoux, Laura ;

Chiforeanu, Dan Cristian ;

Dufrenot, Leila ;

Jauffret, Vincent ;

Dachary, Dominique ;

Corre, Romain ;

Lespagnol, Alexandra ;

Soler, Gwendoline ;

Dagher, Julien ;

Catros, Veronique ;

Le Calve, Michele ;

Merlio, Jean-Philippe ;

Belaud-Rotureau, Marc-Antoine .

JOURNAL OF THORACIC ONCOLOGY, 2014, 9 (03) :295-306

[4] Lung adenocarcinoma with concomitant EGFR mutation and ALK rearrangement [J].

Caliez, J. ;

Monnet, I. ;

Pujals, A. ;

Rousseau-Bussac, G. ;

Jabot, L. ;

Boudjemaa, A. ;

Leroy, K. ;

Chouaid, C. .

REVUE DES MALADIES RESPIRATOIRES, 2017, 34 (05) :576-580

[5] A case of lung adenocarcinoma harboring exon 19 EGFR deletion and EML4-ALK fusion gene [J].

Chen, Xiaoxia ;

Zhang, Jie ;

Hu, Qiong ;

Li, Xuefei ;

Zhou, Caicun .

LUNG CANCER, 2013, 81 (02) :308-310

[6] Long-Term Response to Gefitinib and Crizotinib in Lung Adenocarcinoma Harboring Both Epidermal Growth Factor Receptor Mutation and EML4-ALK Fusion Gene [J].

Chiari, Rita ;

Duranti, Simona ;

Ludovini, Vienna ;

Bellezza, Guido ;

Pireddu, Anjuta ;

Minotti, Vincenzo ;

Bennati, Chiara ;

Crino, Lucio .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (09) :E30-E32

[7] Bone and brain metastasis in lung cancer: recent advances in therapeutic strategies [J].

D'Antonio, Chiara ;

Passaro, Antonio ;

Gori, Bruno ;

Del Signore, Ester ;

Migliorino, Maria Rita ;

Ricciardi, Serena ;

Fulvi, Alberto ;

de Marinis, Filippo .

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2014, 6 (03) :101-114

[8] Mutation incidence and coincidence in non small-cell lung cancer: meta-analyses by ethnicity and histology (mutMap) [J].

Dearden, S. ;

Stevens, J. ;

Wu, Y. -L. ;

Blowers, D. .

ANNALS OF ONCOLOGY, 2013, 24 (09) :2371-2376

[9]

Dempke WCM, 2015, ANTICANCER RES, V35, P5797

[10] Adenocarcinoma of the lung with concomitant ALK fusion gene and EGFR gene mutation: A case report and literature review [J].

Fan, Tao ;

Song, Ying-Jie ;

Liu, Xiu-Li .

MOLECULAR AND CLINICAL ONCOLOGY, 2016, 4 (02) :203-205

← 1 2 3 4 5 6 →