Serum Interleukin-6 Is a Predictive Biomarker for Ketamine's Antidepressant Effect in Treatment-Resistant Patients With Major Depression

被引：146
作者：
Yang, Jian-Jun [1 ]
Wang, Nan [1 ]
Yang, Chun [3 ]
Shi, Jin-Yun [1 ,2 ]
Yu, Hai-Ying [2 ]
Hashimoto, Kenji [3 ]
机构：
[1] Nanjing Univ, Dept Anesthesiol, Jinling Hosp, Sch Med, Nanjing 210008, Jiangsu, Peoples R China
[2] PLA 102nd Hosp & Mental Hlth Ctr Mil, Dept Psychiat, Changzhou, Peoples R China
[3] Chiba Univ, Ctr Forens Mental Hlth, Div Clin Neurosci, Chiba, Japan
来源：
BIOLOGICAL PSYCHIATRY | 2015年 / 77卷 / 03期
关键词：
INFLAMMATION; CYTOKINES;
D O I：
10.1016/j.biopsych.2014.06.021
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
引用
收藏
页码：E19 / E20
页数：2
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[1]   Ketamine for Depression: Where Do We Go from Here? [J].
Aan Het Rot, Marije ;
Zarate, Carlos A., Jr. ;
Charney, Dennis S. ;
Mathew, Sanjay J. .
BIOLOGICAL PSYCHIATRY, 2012, 72 (07) :537-547
[2]   Connecting Inflammation with Glutamate Agonism in Suicidality [J].
Erhardt, Sophie ;
Lim, Chai K. ;
Linderholm, Klas R. ;
Janelidze, Shorena ;
Lindqvist, Daniel ;
Samuelsson, Martin ;
Lundberg, Kristina ;
Postolache, Teodor T. ;
Traskman-Bendz, Lil ;
Guillemin, Gilles J. ;
Brundin, Lena .
NEUROPSYCHOPHARMACOLOGY, 2013, 38 (05) :743-752
[3]   Rapid-Acting Glutamatergic Antidepressants: The Path to Ketamine and Beyond [J].
Krystal, John H. ;
Sanacora, Gerard ;
Duman, Ronald S. .
BIOLOGICAL PSYCHIATRY, 2013, 73 (12) :1133-1141
[4]   Targeting classical IL-6 signalling or IL-6 trans-signalling in depression? [J].
Maes, Michael ;
Anderson, George ;
Kubera, Marta ;
Berk, Michael .
EXPERT OPINION ON THERAPEUTIC TARGETS, 2014, 18 (05) :495-512
[5]   Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression [J].
Miller, Andrew H. ;
Maletic, Vladimir ;
Raison, Charles L. .
BIOLOGICAL PSYCHIATRY, 2009, 65 (09) :732-741
[6]   Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial [J].
Murrough, James W. ;
Losifescu, Dan V. ;
Chang, Lee C. ;
Al Jurdi, Rayan K. ;
Green, Charles E. ;
Perez, Andrew M. ;
Lqbal, Syed ;
Pillemer, Sarah ;
Foulkes, Alexandra ;
Shah, Asim ;
Charney, Dennis S. ;
Mathew, Sanjay J. .
AMERICAN JOURNAL OF PSYCHIATRY, 2013, 170 (10) :1134-1142
[7]   The role of inflammatory cytokines in suicidal behavior: A systematic review [J].
Serafini, Gianluca ;
Pompili, Maurizio ;
Seretti, Maria Elena ;
Stefani, Henry ;
Palermo, Mario ;
Coryell, William ;
Girardi, Paolo .
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2013, 23 (12) :1672-1686
[8]   Human Biomarkers of Rapid Antidepressant Effects [J].
Zarate, Carlos A., Jr. ;
Mathews, Daniel C. ;
Furey, Maura L. .
BIOLOGICAL PSYCHIATRY, 2013, 73 (12) :1142-1155
[9]   Relationship of Ketamine's Plasma Metabolites with Response, Diagnosis, and Side Effects in Major Depression [J].
Zarate, Carlos A., Jr. ;
Brutsche, Nancy ;
Laje, Gonzalo ;
Luckenbaugh, David A. ;
Venkata, Swarajya L. Vattem ;
Ramamoorthy, Anuradha ;
Moaddel, Ruin ;
Wainer, Irving W. .
BIOLOGICAL PSYCHIATRY, 2012, 72 (04) :331-338
[10]   Ketamine: synaptogenesis, immunomodulation and glycogen synthase kinase-3 as underlying mechanisms of its antidepressant properties [J].
Zunszain, P. A. ;
Horowitz, M. A. ;
Cattaneo, A. ;
Lupi, M. M. ;
Pariante, C. M. .
MOLECULAR PSYCHIATRY, 2013, 18 (12) :1236-1241
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