Liquid biopsy in bladder cancer: State of the art and future perspectives

被引：71

作者：

Crocetto, Felice ^{[1
]}

Barone, Biagio ^{[1
]}

Ferro, Matteo ^{[2
]}

Busetto, Gian Maria ^{[3
]}

La Civita, Evelina ^{[4
]}

Buonerba, Carlo ^{[5
]}

Di Lorenzo, Giuseppe ^{[5
,7
]}

Terracciano, Daniela ^{[4
]}

Schalken, Jack A. ^{[6
]}

机构：

[1] Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, Naples, Italy

[2] IEO European Inst Oncol IRCCS, Dept Urol, Milan, Italy

[3] Univ Foggia, Dept Med & Surg Sci, Urol & Renal Transplantat Unit, Foggia, Italy

[4] Univ Naples Federico II, Dept Translat Med Sci, Naples, Italy

[5] Hosp Andrea Tortora, Oncol Unit, ASL Salerno, Pagani, Italy

[6] Radboud Univ Nijmegen, Dept Urol, Med Ctr, Nijmegen, Netherlands

[7] Univ Molise, Dept Med & Hlth Sci, Campobasso, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2022年 / 170卷

关键词：

Urinary biomarker; Bladder cancer; Liquid biopsy; Cytology; URINE CYTOLOGY; FOLLOW-UP; CYFRA; 21-1; CYTOKERATIN-19; FRAGMENT; UROTHELIAL CARCINOMA; DIAGNOSTIC-ACCURACY; IMMUNOCYT TEST; RAPID TEST; SURVEILLANCE; MUTATIONS;

D O I：

10.1016/j.critrevonc.2022.103577

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bladder cancer is the most common malignancy of the urinary tract. Cystoscopy represents the gold standard in the diagnosis of suspicious bladder lesions. However, the procedure is invasive and burdened by pain, discomfort and infective complications. Cytology, which represents an alternative diagnostic possibility is limited by poor sensitivity. Considering the limitations of both procedures, and the necessity to perform multiple evaluations in patients who are in follow-up for bladder cancer, an improved non-invasive methodology is required in the clinical management of this disease. Liquid biopsy, e.g. the detection of clinical biomarkers in urine, represent a promising novel and non-invasive approach that could overcome those limitations and be integrated into the current clinical practice. The aim of this review is to summarize the state of the art of this approach and the latest novelties regarding detection, prognosis and surveillance of bladder cancer.

引用

页数：9

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