Controllable synthesis of spherical hydroxyapatite nanoparticles using inverse microemulsion method

被引：44
作者：
Ma, Xiaoyu [1 ,2 ]
Chen, Yaying [2 ]
Qian, Jiangchao [3 ]
Yuan, Yuan [1 ,2 ,3 ]
Liu, Changsheng [1 ,2 ,3 ]
机构：
[1] East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China
[2] East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China
[3] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
来源：
MATERIALS CHEMISTRY AND PHYSICS | 2016年 / 183卷
基金：
中国国家自然科学基金;
关键词：
Microemulsion; Hydroxyapatite; Spherical nano particle; CALCIUM-PHOSPHATE NANOPARTICLES; HYDROTHERMAL SYNTHESIS; NANO; AGGLOMERATION; MICROSPHERES; PARTICLES; KINETICS; SIZE;
D O I：
10.1016/j.matchemphys.2016.08.021
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Spherical nanosized hydroxyapatite (HA) was successfully synthesized via a water-in-oil microemulsion route at room temperature in short time. The effect of water-to-oil and water-to-surfactant ratios on the stability of microemulsion system was investigated to establish a stable reaction system, with span-80, cyclohexane and Ca(NO3)(2)center dot 4H(2)O((NH4)(2)HPO4) solution as surfactant, oil phase, and water phase, respectively. Size and morphology change of obtained HA under optimal microemulsion system were further studied under various reaction time and temperature, and a possible growth mechanism was proposed. A moderate reaction temperature of 25 degrees C and reaction time of 5 h facilitated the formation of spherical HA particles in the dimension of 70 nm with good uniformity and regularity, which served as a great candidate in biomedical applications. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：220 / 229
页数：10
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