Regulation of osteoclast-mediated bone resorption by microRNA

被引：13
|
作者：
Ji, Ling [1 ]
Li, Xinyi [1 ]
He, Shushu [1 ]
Chen, Song [1 ]
机构：
[1] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis,Dept Orthodont, Chengdu, Sichuan, Peoples R China
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2022年 / 79卷 / 06期
基金：
中国国家自然科学基金;
关键词：
MicroRNA; Osteoclast; Bone resorption; Signaling pathways; NF-KAPPA-B; RANKL-INDUCED OSTEOCLASTOGENESIS; CELL LUNG-CANCER; PROMOTES OSTEOCLASTOGENESIS; NEGATIVE REGULATION; DOWN-REGULATION; POSTMENOPAUSAL OSTEOPOROSIS; MURINE OSTEOCLASTOGENESIS; SIGNAL-TRANSDUCTION; ESTROGEN DEFICIENCY;
D O I：
10.1007/s00018-022-04298-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Osteoclast-mediated bone resorption is responsible for bone metabolic diseases, negatively impacting people's health and life. It has been demonstrated that microRNA influences the differentiation of osteoclasts by regulating the signaling pathways during osteoclast-mediated bone resorption. So far, the involved mechanisms have not been fully elucidated. This review introduced the pathways involved in osteoclastogenesis and summarized the related microRNAs binding to their specific targets to mediate the downstream pathways in osteoclast-mediated bone resorption. We also discuss the clinical potential of targeting microRNAs to treat osteoclast-mediated bone resorption as well as the challenges of avoiding potential side effects and producing efficient delivery methods.
引用
收藏
页数：25
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