HIV-inhibitory natural products.: 49.: Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii

被引：94

作者：

Fuller, RW ^{[1
]}

Blunt, JW ^{[1
]}

Boswell, JL ^{[1
]}

Cardellina, JH ^{[1
]}

Boyd, MR ^{[1
]}

机构：

[1] NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 01期

关键词：

D O I：

10.1021/np9801514

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The HIV-inhibitory activity in extracts of Allanblackia stuhlmannii was tracked, via bioassay-guided fractionation, to a new member of the camboginol/guttiferone class of prenylated benzophenones, guttiferone F (1). The structure was solved by extensive NMR analyses and by acid-catalyzed conversion to 30-epi-cambogin (4). This is the first report of this compound type in the genus Allanblackia.

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页码：130 / 132

页数：3

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