HIV-inhibitory natural products.: 49.: Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii

被引：94
作者：
Fuller, RW [1 ]
Blunt, JW [1 ]
Boswell, JL [1 ]
Cardellina, JH [1 ]
Boyd, MR [1 ]
机构：
[1] NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 01期
关键词：
D O I：
10.1021/np9801514
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The HIV-inhibitory activity in extracts of Allanblackia stuhlmannii was tracked, via bioassay-guided fractionation, to a new member of the camboginol/guttiferone class of prenylated benzophenones, guttiferone F (1). The structure was solved by extensive NMR analyses and by acid-catalyzed conversion to 30-epi-cambogin (4). This is the first report of this compound type in the genus Allanblackia.
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页码：130 / 132
页数：3
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