Non-psychiatric comorbidity associated with Alzheimer's disease

被引：70

作者：

Duthie, A. ^{[2
]}

Chew, D. ^{[1
]}

Soiza, R. L. ^{[1
]}

机构：

[1] Woodend Gen Hosp, Dept Med Elderly, Aberdeen AB15 6XS, Scotland

[2] Royal Cornhill Hosp, Old Age Psychiat Directorate, Aberdeen, Scotland

来源：

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE | 2011年 / 104卷 / 11期

关键词：

OBSTRUCTIVE SLEEP-APNEA; MIDLIFE BLOOD-PRESSURE; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; APOLIPOPROTEIN-E POLYMORPHISM; AMYLOID PRECURSOR PROTEIN; BONE-MINERAL DENSITY; COGNITIVE DECLINE; THYROID-FUNCTION; METABOLIC SYNDROME; DIABETES-MELLITUS;

D O I：

10.1093/qjmed/hcr118

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The burden of medical comorbidity in individuals with Alzheimer's disease is greater than that observed in matched individuals without dementia. This has important implications for all clinicians and healthcare providers who deal with this common condition. The prevalence of vascular risk factors and vascular disease is particularly high. Additionally, associations with a number of other chronic medical conditions have been described, including thyroid disorders, sleep apnoea, osteoporosis and glaucoma. This review gives an overview of evidenced medical (non-psychiatric) comorbidity associated with Alzheimer's disease and briefly explores the underlying mechanisms that may account for these associations.

引用

页码：913 / 920

页数：8

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